Qiwei Qin

Summary

Affiliation: South China Sea Institute of Oceanology
Country: China

Publications

  1. Luo S, Huang Y, Xie F, Huang X, Liu Y, Wang W, et al. Molecular cloning, characterization and expression analysis of PPAR gamma in the orange-spotted grouper (Epinephelus coioides) after the Vibrio alginolyticus challenge. Fish Shellfish Immunol. 2015;43:310-24 pubmed publisher
    ..Together, these results indicated that EcPPAR gamma serving as a negative regulator of pro-inflammatory cytokines may play an important role in the immune defense against vibrio-induced inflammation in grouper. ..
  2. Cai J, Wei S, Lu Y, Wu Z, Qin Q, Jian J. Bax inhibitor-1 from orange spotted grouper, Epinephelus coioides involved in viral infection. Fish Shellfish Immunol. 2018;78:91-99 pubmed publisher
    ..In addition, EcBI-1 could interact with EcBNIP3 in vitro. Together, our data firstly demonstrated that fish BI-1 play important roles in response to viral infection. ..
  3. Huang Y, Huang X, Yang Y, Wang W, Yu Y, Qin Q. Involvement of fish signal transducer and activator of transcription 3 (STAT3) in nodavirus infection induced cell death. Fish Shellfish Immunol. 2015;43:241-8 pubmed publisher
    ..Together, our results not only firstly revealed that STAT3 exerted novel roles in response to fish virus infection, but also provided new insights into understanding the roles of STAT3 in different forms of programmed cell death. ..
  4. Huang X, Wang W, Huang Y, Xu L, Qin Q. Involvement of the PI3K and ERK signaling pathways in largemouth bass virus-induced apoptosis and viral replication. Fish Shellfish Immunol. 2014;41:371-9 pubmed publisher
    ..Taken together, our results provided new insights into the molecular mechanism of ranavirus infection. ..
  5. Huang X, Huang Y, Yang Y, Wei S, Qin Q. Involvement of fish signal transducer and activator of transcription 3 (STAT3) in SGIV replication and virus induced paraptosis. Fish Shellfish Immunol. 2014;41:308-16 pubmed publisher
    ..Together, our results firstly demonstrated the critical roles of fish STAT3 in DNA virus replication and virus induced paraptosis, but also provided new insights into the mechanism of iridovirus pathogenesis. ..
  6. Wei J, Zhang P, Guo M, Xu M, Li P, Chen X, et al. TTRAP is a critical factor in grouper immune response to virus infection. Fish Shellfish Immunol. 2015;46:274-84 pubmed publisher
    ..The present results provided new evidences for the potential roles of such molecule in E. coioides, and further confirmed the existence of TTRAP modulated TNF signaling pathway in grouper. ..
  7. Wei S, Huang Y, Huang X, Qin Q. Characterization of c-Jun from orange-spotted grouper, Epinephelus coioides involved in SGIV infection. Fish Shellfish Immunol. 2015;43:230-40 pubmed publisher
    ..Thus, we proposed that c-Jun transcription factor was essential for SGIV replication in vitro. Our results will contribute to understanding the crucial roles of JNK signaling pathway in fish virus infection. ..
  8. Wei J, Gao P, Zhang P, Guo M, Xu M, Wei S, et al. Isolation and function analysis of apolipoprotein A-I gene response to virus infection in grouper. Fish Shellfish Immunol. 2015;43:396-404 pubmed publisher
    ..Overexpression of Ec-ApoA-I in grouper Brain (GB) cells could inhibit the replication of SGIV. These results together indicated that Ec-ApoA-I perhaps is involved in the responses to bacterial and viral challenge. ..
  9. Cai J, Yu D, Wei S, Tang J, Lu Y, Wu Z, et al. Identification of the Bcl-2 family protein gene BOK from orange-spotted grouper (Epinephelus coioides) involved in SGIV infection. Fish Shellfish Immunol. 2016;52:9-15 pubmed publisher
    ..Further analysis revealed that overexpression of Ec-BOK inhibited viral genes transcriptions and virus replication in fish cell. Our findings suggested that Ec-BOK might play a role in the immune response against virus. ..

More Information

Publications40

  1. Wei J, Zang S, Xu M, Zheng Q, Chen X, Qin Q. TRAF6 is a critical factor in fish immune response to virus infection. Fish Shellfish Immunol. 2017;60:6-12 pubmed publisher
    ..Therefore, these results suggest that TRAF6 may play a critical role in their response to SGIV infection, through regulation of a cell death pathway that is common to fish and humans. ..
  2. Xie H, Wei J, Qin Q. Antiviral function of Tachyplesin I against iridovirus and nodavirus. Fish Shellfish Immunol. 2016;58:96-102 pubmed publisher
    ..1-flag-Tac I after infection with SGIV and VNNV. These results suggest that Tachyplesin I is importantly involved in host immune responses to invasion of viral pathogens. ..
  3. Yu Y, Huang X, Liu J, Zhang J, Hu Y, Yang Y, et al. Fish TRIM32 functions as a critical antiviral molecule against iridovirus and nodavirus. Fish Shellfish Immunol. 2017;60:33-43 pubmed publisher
    ..Together, our results firstly demonstrated that fish TRIM32 acted as an antiviral factor against both DNA and RNA virus infection. ..
  4. Yang Y, Huang Y, Yu Y, Zhou S, Wang S, Yang M, et al. Negative regulation of the innate antiviral immune response by TRIM62 from orange spotted grouper. Fish Shellfish Immunol. 2016;57:68-78 pubmed publisher
    ..Thus, our studies firstly demonstrated that EcTRIM62 negatively regulated the innate antiviral immune response against fish RNA viruses. ..
  5. Guo M, Wei J, Zhou Y, Qin Q. c-Jun N-terminal kinases 3 (JNK3) from orange-spotted grouper, Epinephelus coioides, inhibiting the replication of Singapore grouper iridovirus (SGIV) and SGIV-induced apoptosis. Dev Comp Immunol. 2016;65:169-181 pubmed publisher
    ..Our results not only define the characterization of JNK3 but also reveal new immune functions and the molecular mechanisms of JNK3 on iridoviruses infection and the virus-induced apoptosis. ..
  6. Huang Y, Yang M, Yu Y, Yang Y, Zhou L, Huang X, et al. Grouper TRIM13 exerts negative regulation of antiviral immune response against nodavirus. Fish Shellfish Immunol. 2016;55:106-15 pubmed publisher
    ..Together, our results firstly demonstrated that fish TRIM13 exerted negative regulation of antiviral response against nodavirus infection. ..
  7. Huang Y, Yu Y, Yang Y, Yang M, Zhou L, Huang X, et al. Antiviral function of grouper MDA5 against iridovirus and nodavirus. Fish Shellfish Immunol. 2016;54:188-96 pubmed publisher
    ..Together, our results demonstrated for the first time that the inhibitory effect of fish MDA5 on iridovirus replication might be mainly through the regulation of proinflammatory cytokines. ..
  8. Li P, Zhou L, Ni S, Xu M, Yu Y, Cai J, et al. Establishment and characterization of a novel cell line from the brain of golden pompano (Trachinotus ovatus). In Vitro Cell Dev Biol Anim. 2016;52:410-8 pubmed publisher
    ..TOGB cells were diploid (2N = 54). The transfection efficiencies of TOGB cells were 8.6% at the 15th passage and 64.8% at the 45th passage, indicating that the cells are suitable for foreign gene expression. ..
  9. Guo M, Wei J, Zhou Y, Qin Q. Molecular clone and characterization of c-Jun N-terminal kinases 2 from orange-spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 2016;49:355-63 pubmed publisher
    ..These results indicated that Ec-JNK2 could be an important molecule in the successful infection and evasion of SGIV. ..
  10. Wei J, Xu M, Chen X, Zhang P, Li P, Wei S, et al. Function analysis of fish Tollip gene in response to virus infection. Fish Shellfish Immunol. 2015;47:807-16 pubmed publisher
    ..Taken together, the results provide new insights in to the importance of Tollip as evolutionarily conserved molecule for grouper innate immunity against virus infection. ..
  11. Zhou L, Li P, Yang M, Yu Y, Huang Y, Wei J, et al. Generation and characterization of novel DNA aptamers against coat protein of grouper nervous necrosis virus (GNNV) with antiviral activities and delivery potential in grouper cells. Antiviral Res. 2016;129:104-114 pubmed publisher
    ..These aptamers hold promise as diagnostic, therapeutic, and targeted drug delivery agents for controlling NNV infections. ..
  12. Wang W, Huang Y, Yu Y, Yang Y, Xu M, Chen X, et al. Fish TRIM39 regulates cell cycle progression and exerts its antiviral function against iridovirus and nodavirus. Fish Shellfish Immunol. 2016;50:1-10 pubmed publisher
    ..Together, our results demonstrated that fish TRIM39 not only regulated the cell cycle progression, but also acted as an important regulator of fish innate immune response against viruses. ..
  13. Chen X, Wei J, Xu M, Yang M, Li P, Wei S, et al. Molecular cloning and characterization of a galectin-1 homolog in orange-spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 2016;54:333-41 pubmed publisher
    ..Taken together, the results showed that EcGel-1 may be an important molecule involved in pathogen recognition and pathogen elimination in the innate immunity of grouper. ..
  14. Yang Y, Huang Y, Yu Y, Yang M, Zhou S, Qin Q, et al. RING domain is essential for the antiviral activity of TRIM25 from orange spotted grouper. Fish Shellfish Immunol. 2016;55:304-14 pubmed publisher
    ..Together, our results will provide new evidences that the RING domain was essential for the antiviral action of fish TRIM25 against iridovirus and nodavirus infection. ..
  15. Li P, Zhou L, Yu Y, Yang M, Ni S, Wei S, et al. Characterization of DNA aptamers generated against the soft-shelled turtle iridovirus with antiviral effects. BMC Vet Res. 2015;11:245 pubmed publisher
    ..These DNA aptamers may thus be suitable antiviral candidates for the control of STIV infections. ..
  16. Yu Y, Huang Y, Yang Y, Wang S, Yang M, Huang X, et al. Negative regulation of the antiviral response by grouper LGP2 against fish viruses. Fish Shellfish Immunol. 2016;56:358-366 pubmed publisher
    ..Thus, our results will contribute greatly to understanding the roles of fish LGP2 in innate immune response during iridovirus and nodavirus infection. ..
  17. Guo M, Wei J, Zhou Y, Qin Q. MKK7 confers different activities to viral infection of Singapore grouper iridovirus (SGIV) and nervous necrosis virus (NNV) in grouper. Fish Shellfish Immunol. 2016;57:419-427 pubmed publisher
    ..All results demonstrated that Ec-MKK7 could play important roles in grouper innate immunity and show distinct functions on virus infection. ..
  18. Gao R, Huang Y, Huang X, Guan L, Wei S, Zhou Y, et al. Molecular cloning and characterization of two types of I?B? orthologues in orange-spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 2014;38:101-10 pubmed publisher
    ..Taken together, our findings suggested that both EcI?B?A and EcI?B?B were involved in grouper innate immunity against virus. ..
  19. Hu Y, Huang Y, Liu J, Zhang J, Qin Q, Huang X. TBK1 from orange-spotted grouper exerts antiviral activity against fish viruses and regulates interferon response. Fish Shellfish Immunol. 2018;73:92-99 pubmed publisher
    ..Together, we speculated that grouper TBK1 exerted antiviral activity against iridovirus and nodavirus via regulating the interferon immune and inflammatory response. ..
  20. Jia K, Yuan Y, Liu W, Liu L, Qin Q, Yi M. Identification of Inhibitory Compounds Against Singapore Grouper Iridovirus Infection by Cell Viability-Based Screening Assay and Droplet Digital PCR. Mar Biotechnol (NY). 2018;20:35-44 pubmed publisher
    ..These findings provided an easy and reliable cell viability-based screening assay to identify compounds with anti-SGIV effect and a way of studying the anti-SGIV mechanism of compounds. ..
  21. Huang Y, Zhang J, Liu J, Hu Y, Ni S, Yang Y, et al. Fish TRIM35 negatively regulates the interferon signaling pathway in response to grouper nodavirus infection. Fish Shellfish Immunol. 2017;69:142-152 pubmed publisher
    ..Thus, our results will shed new lights on the roles of fish TRIM35 in innate immune response against grouper virus infection. ..
  22. Huang Y, Huang X, Cai J, Ouyang Z, Wei S, Wei J, et al. Identification of orange-spotted grouper (Epinephelus coioides) interferon regulatory factor 3 involved in antiviral immune response against fish RNA virus. Fish Shellfish Immunol. 2015;42:345-52 pubmed publisher
    ..Together, our results demonstrated that IFN immune response mediated by grouper IRF3 was exerted crucial roles for fish RNA virus, but not for DNA virus replication. ..
  23. Yan Y, Guo C, Ni S, Wei J, Li P, Wei S, et al. Singapore grouper iridovirus (SGIV) encoded SGIV-miR-13 attenuates viral infection via modulating major capsid protein expression. Virus Res. 2015;205:45-53 pubmed publisher
    ..The detailed investigation of SGIV encoded miRNAs may provide new insights into the mechanism of iridovirus pathogenesis. ..
  24. Yu Y, Huang X, Zhang J, Liu J, Hu Y, Yang Y, et al. Fish TRIM16L exerts negative regulation on antiviral immune response against grouper iridoviruses. Fish Shellfish Immunol. 2016;59:256-267 pubmed publisher
    ..Our data, for the first time, demonstrated that fish TRIM16L exerted negative regulation on the interferon immune response against DNA virus infection. ..
  25. Guo C, Cui H, Ni S, Yan Y, Qin Q. Comprehensive identification and profiling of host miRNAs in response to Singapore grouper iridovirus (SGIV) infection in grouper (Epinephelus coioides). Dev Comp Immunol. 2015;52:226-35 pubmed publisher
    ..5-fold) were identified by miRNA microarray assays in grouper spleen tissues and GS cells, respectively. Furthermore, target prediction revealed 189 putative targets of these grouper miRNAs. ..
  26. Xu M, Wei J, Chen X, Gao P, Zhou Y, Qin Q. Molecular cloning and expression analysis of small ubiquitin-like modifier (SUMO) genes from grouper (Epinephelus coioides). Fish Shellfish Immunol. 2016;48:119-27 pubmed publisher
    ..Our study was an important attempt to understand the SUMO pathway in fish, which may provide insights into the regulatory mechanism of viral infection in E.coioides under farmed conditions. ..
  27. Huang Y, Ouyang Z, Wang W, Yu Y, Li P, Zhou S, et al. Antiviral role of grouper STING against iridovirus infection. Fish Shellfish Immunol. 2015;47:157-67 pubmed publisher
    ..Together, our results demonstrated that EcSTING might be an important regulator of grouper innate immune response against iridovirus infection. ..
  28. Huang Y, Zhang J, Ouyang Z, Liu J, Zhang Y, Hu Y, et al. Grouper MAVS functions as a crucial antiviral molecule against nervous necrosis virus infection. Fish Shellfish Immunol. 2018;72:14-22 pubmed publisher
    ..Taken together, our results demonstrated that grouper MAVS exerted antiviral function against nodavirus infection via up-regulating the interferon immune response. ..
  29. Ni S, Yu Y, Wei J, Zhou L, Wei S, Yan Y, et al. MicroRNA-146a promotes red spotted grouper nervous necrosis virus (RGNNV) replication by targeting TRAF6 in orange spotted grouper, Epinephelus coioides. Fish Shellfish Immunol. 2018;72:9-13 pubmed publisher
    ..Thus, our results suggested and verified that holding the level of miR-146a exerted crucial roles in RGNNV infection through TRAF6-mediated inflammatory response. ..
  30. Huang Y, Yu Y, Yang Y, Yang M, Zhou L, Huang X, et al. Fish TRIM8 exerts antiviral roles through regulation of the proinflammatory factors and interferon signaling. Fish Shellfish Immunol. 2016;54:435-44 pubmed publisher
    ..Together, our results firstly demonstrated that fish TRIM8 could exert antiviral function through the regulation of the expression of proinflammatory cytokines and interferon related transcription factors in response to fish viruses. ..
  31. Huang Y, Huang X, Yan Y, Cai J, Ouyang Z, Cui H, et al. Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Singapore grouper iridovirus. BMC Genomics. 2011;12:556 pubmed publisher
    ..In this study, we used a 454 pyrosequencing method to investigate differentially-expressed genes in the spleen of the E. coioides infected with Singapore grouper iridovirus (SGIV)...