Affiliation: Lanzhou University
Nan J, Du Y, Chen X, Bai Q, Wang Y, Zhang X, et al
. TPCA-1 is a direct dual inhibitor of STAT3 and NF-?B and regresses mutant EGFR-associated human non-small cell lung cancers. Mol Cancer Ther. 2014;13:617-29 pubmed publisher
..Therefore, synergistic treatment of TPCA-1 with TKIs has potential to be a more effective strategy for cancers. ..
Zhang J, Zhu N, Du Y, Bai Q, Chen X, Nan J, et al
. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015;87:572-81 pubmed publisher
..Importantly, dehydrocrenatidine does not show significant effect on Src overexpression and epidermal growth factor-induced STAT3 activation. Our results indicate that dehydrocrenatidine is a JAK-specific inhibitor. ..
Zhu N, Zhang J, Qin X, Miao R, Du Y, Yang J. ZIP restores estrogen receptor expression and response to Tamoxifen in estrogen receptor negative tumors. Biochem Biophys Res Commun. 2016;480:570-573 pubmed publisher
..Overexpression of ZIP suppressed EGFR expression level and restored ERalpha protein level in cells resistant to Tamoxifen. In vivo data confirmed those in vitro findings. ..
Yang J, Huang J, Dasgupta M, Sears N, Miyagi M, Wang B, et al
. Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A. 2010;107:21499-504 pubmed publisher