Yang Ke

Summary

Affiliation: Chinese Academy of Sciences
Country: China

Publications

  1. pmc Si-RNA mediated knockdown of CELF1 gene suppressed the proliferation of human lung cancer cells
    Li na Wu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Thoracic Surgery II, Peking University Cancer Hospital and Institute, Beijing 100142, China
    Cancer Cell Int 13:115. 2013
  2. pmc Reliable management of post-esophagectomy anastomotic fistula with endoscopic trans-fistula negative pressure drainage
    Yi Nan Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Thoracic Surgery II, Peking University Cancer Hospital and Institute, 100142 Beijing, People s Republic of China
    World J Surg Oncol 12:240. 2014
  3. pmc Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma
    Yinan Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Thoracic Surgery II, Peking University Cancer Hospital and Institute, Beijing 100142, People s Republic of China
    World J Surg Oncol 12:43. 2014
  4. pmc The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions
    Mu Hu
    Cardiff University Capital Medical University Joint Centre for Biomedical Research, Cardiff, UK
    BMC Cancer 12:588. 2012
  5. pmc Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, China
    World J Surg Oncol 3:68. 2005
  6. pmc The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance
    Fei Xie
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF144XN, UK
    J Transl Med 9:95. 2011
  7. ncbi request reprint [Expression of placental growth factor and pigment epithelium-derived factor in non-small cell lung cancer and the prognostic significance thereof]
    Li Jian Zhang
    Department of Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China Email
    Zhonghua Yi Xue Za Zhi 85:3328-31. 2005
  8. ncbi request reprint Expression of pigment epithelial derived factor is reduced in non-small cell lung cancer and is linked to clinical outcome
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, PR China
    Int J Mol Med 17:937-44. 2006
  9. pmc Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits
    Jianguo Wu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
    PLoS ONE 7:e31692. 2012
  10. pmc The Willingness to Change Risky Health Behaviors among Chinese Rural Residents: What We Learned from a Population-Based Esophageal Cancer Cohort Study
    Mengfei Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Haidian District, Beijing, People s Republic of China
    PLoS ONE 11:e0161999. 2016

Collaborators

Detail Information

Publications36

  1. pmc Si-RNA mediated knockdown of CELF1 gene suppressed the proliferation of human lung cancer cells
    Li na Wu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Thoracic Surgery II, Peking University Cancer Hospital and Institute, Beijing 100142, China
    Cancer Cell Int 13:115. 2013
    ..As yet, there is little knowledge of CELF1 expression and biological function in lung cancer. This study investigated the expression levels of CELF1 in lung cancer tissues and the biological function of CELF1 in lung cancer cells...
  2. pmc Reliable management of post-esophagectomy anastomotic fistula with endoscopic trans-fistula negative pressure drainage
    Yi Nan Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Thoracic Surgery II, Peking University Cancer Hospital and Institute, 100142 Beijing, People s Republic of China
    World J Surg Oncol 12:240. 2014
    ..To promote fistula closure, we developed a modified endoscopic method of trans-fistula drainage with persistent negative pressure. In this study, we aimed to evaluate the efficacy of this endoscopic therapy...
  3. pmc Clinical value of hematologic test in predicting tumor response to neoadjuvant chemotherapy with esophageal squamous cell carcinoma
    Yinan Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Thoracic Surgery II, Peking University Cancer Hospital and Institute, Beijing 100142, People s Republic of China
    World J Surg Oncol 12:43. 2014
    ....
  4. pmc The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions
    Mu Hu
    Cardiff University Capital Medical University Joint Centre for Biomedical Research, Cardiff, UK
    BMC Cancer 12:588. 2012
    ....
  5. pmc Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, China
    World J Surg Oncol 3:68. 2005
    ..This study examined PlGF expression at protein and message levels in non-small cell lung cancer (NSCLC), in which no reports on the significance of PlGF expression is available to date...
  6. pmc The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance
    Fei Xie
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff CF144XN, UK
    J Transl Med 9:95. 2011
    ..Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma (ESCC) has not been reported...
  7. ncbi request reprint [Expression of placental growth factor and pigment epithelium-derived factor in non-small cell lung cancer and the prognostic significance thereof]
    Li Jian Zhang
    Department of Surgery, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China Email
    Zhonghua Yi Xue Za Zhi 85:3328-31. 2005
    ....
  8. ncbi request reprint Expression of pigment epithelial derived factor is reduced in non-small cell lung cancer and is linked to clinical outcome
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Haidian District, Beijing, PR China
    Int J Mol Med 17:937-44. 2006
    ..PEDF is an important factor in NSCLC development and may be a of prognostic value for NSCLC patients...
  9. pmc Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits
    Jianguo Wu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
    PLoS ONE 7:e31692. 2012
    ..U3 small nucleolar RNA (snoRNA) directs 18S rRNA processing and U8 snoRNA mediates processing of 28S and 5.8 S rRNAs. Functional disruption of nucleolus often causes p53 activation to inhibit cell proliferation...
  10. pmc The Willingness to Change Risky Health Behaviors among Chinese Rural Residents: What We Learned from a Population-Based Esophageal Cancer Cohort Study
    Mengfei Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Haidian District, Beijing, People s Republic of China
    PLoS ONE 11:e0161999. 2016
    ..However, the specifics of this problem in rural China are still unclear, and appropriate strategies should be explored...
  11. pmc Human papillomavirus DNA positivity and seropositivity in rural Chinese men and women: a population-based cross-sectional study
    Fangfang Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Beijing, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Beijing, China
    Sci Rep 6:26343. 2016
    ..These findings may reflect a site-specific natural course of HPV infection and further understanding of the epidemiology of HPV. ..
  12. pmc Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential
    Yong Li
    Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Genetics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Hai Dian District, Beijing 100142, China
    BMC Cancer 11:121. 2011
    ..Here, we examined latexin expression in human gastric carcinomas and investigated the effect of differential latexin expression on proliferation of gastric cancer cells in vitro and in vivo...
  13. ncbi request reprint Down-regulation of PEDF expression by ribozyme transgene in endothelial and lung cancer cells and its impact on angiogenesis in vitro
    Lijian Zhang
    Department of Surgery, Peking University School of Oncology, Peking University, 38 Xueyuan Road, Haidian District, Beijing, PR China
    Oncol Rep 14:1615-9. 2005
    ..Expression of PEDF in both cancer cells and endothelial cells are correlated with the angiogenic process' paracrine and autocrine pattern...
  14. pmc Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China
    Fangfang Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Beijing, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Beijing, China
    Sci Rep 5:15637. 2015
    ..6, 95% CI: 1.0-7.0; 2 partners vs. 1 partner). These findings provide a basis for further understanding the natural history and transmission dynamics of oral HPV infection. ..
  15. pmc Identification and characterization of eleven novel human gamma-papillomavirus isolates from healthy skin, found at low frequency in a normal population
    Jingjing Li
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital and Institute, Beijing, China
    PLoS ONE 8:e77116. 2013
    ..In addition, HPV 161, HPV 162, and HPV 166 may form a new HPV species of the γ-PV genus. The prevalence of these HPV types in the normal population is low. ..
  16. doi request reprint Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population
    Jiang Chang
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Carcinogenesis 34:1782-6. 2013
    ..0001). Our results indicate that incorporating genetic variants, lifestyle factors and their interactions in ESCC risk models can be useful for identifying patients with ESCC. ..
  17. pmc hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF)
    RuiRui Kong
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, China
    J Biol Chem 286:7139-48. 2011
    ..Thus, we provide a mechanism in which a novel t-UTP activates Pol I transcription by binding and acetylating UBF...
  18. pmc The Anyang Esophageal Cancer Cohort Study: study design, implementation of fieldwork, and use of computer-aided survey system
    Fangfang Liu
    Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, People s Republic of China
    PLoS ONE 7:e31602. 2012
    ..However, the causal relationship between HPV infection and the onset of ESCC remains unknown. A large cohort study focusing on this topic is being carried out in rural Anyang, China...
  19. pmc NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2
    Xiaofeng Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Health Science Center, Beijing, China Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    EMBO Rep 17:349-66. 2016
    ..Thus, our data demonstrate that NAT10 plays a critical role in p53 activation via acetylating p53 and counteracting Mdm2 action, providing a novel pathway by which nucleolar protein activates p53 as a cellular stress sensor. ..
  20. doi request reprint Identification of novel alternative splicing variants of interferon regulatory factor 3
    Yong Li
    Key laboratory of Carcinogenesis and Translational Research, Department of Genesis, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, PR China
    Biochim Biophys Acta 1809:166-75. 2011
    ..Taken together, our findings suggest novel splicing variants may function as negative modulators of IRF-3 and may be correlated with pathogenesis of human tumors...
  21. doi request reprint Economic burden of gastrointestinal cancer under the protection of the New Rural Cooperative Medical Scheme in a region of rural China with high incidence of oesophageal cancer: cross-sectional survey
    Xiang Li
    Key laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital and Institute, Beijing, China
    Trop Med Int Health 21:907-16. 2016
    ..To evaluate the financial burden of oesophageal cancer under the protection of the new Rural Cooperative Medical Scheme (NCMS) and to provide evidence and suggestions to policymakers in a high-incidence region in China...
  22. pmc Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology
    Ying Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Beijing, Laboratory of Genetics, Peking University Cancer Hospital and Institute, No 52 Fucheng Road, Haidian District, Beijing 100142, China
    Sci Rep 6:35427. 2016
    ..Our study accurately evaluated HPV integration level in CINs and normal cervical tissues using high-throughput viral integration detection method providing basic evidence for HPV integration-driven cervical carcinogenesis...
  23. doi request reprint Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants
    Dong Hang
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Beijing, China
    J Med Virol 86:618-26. 2014
    ..Collectively, these data indicate the altered functions of HPV16 E6 and E2 by certain variations, which may influence the potential of viral carcinogenesis...
  24. pmc Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China
    Min Sun
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital and Institute, Beijing, China
    PLoS ONE 7:e36577. 2012
    ....
  25. pmc Genome-wide analysis of Epstein-Barr virus (EBV) isolated from EBV-associated gastric carcinoma (EBVaGC)
    Ying Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Haidian, Beijing, China
    Oncotarget 7:4903-14. 2016
    ....
  26. pmc Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technology
    Ying Liu
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Laboratory of Genetics, Peking University Cancer Hospital and Institute, Beijing, China
    Oncotarget 7:5852-64. 2016
    ..The results expand on knowledge from previous findings on HPV16 and HPV18 integration sites and allow a better understanding of the molecular basis of the pathogenesis of cervical carcinoma. ..
  27. pmc Nine complete genome sequences of cutaneous human papillomavirus genotypes isolated from healthy skin of individuals living in rural He Nan province, China
    Jingjing Li
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital and Institute, Beijing, China
    J Virol 86:11936. 2012
    ..All of these isolates belong to the genus Gammapapillomavirus. These data will provide us with useful information for a better understanding of PV evolution and the relationship of PV with the host...
  28. ncbi request reprint [Gene expression profiling study of HPV-16 positive and HPV-negative esophageal squamous cell carcinoma]
    Na Shen
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Department of Genetics, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:723-6. 2011
    ..To study the difference in gene expression between human papillomavirus (HPV)16-positive and HPV-negative esophageal squamous cell carcinoma(ESCC) ...
  29. pmc Conversion of cadherin isoforms in cultured human gastric carcinoma cells
    Bing Jing Wang
    Beijing Institute for Cancer Research, Peking University, Beijing 100036, China
    World J Gastroenterol 12:966-70. 2006
    ..To explore the expression of cadherin isoforms in cultured human gastric carcinoma cells and its regulation...
  30. ncbi request reprint [Clinical analysis of 123 gastric cardia carcinoma patients treated with surgical operation]
    Hong chao Xiong
    Department of Thoracic Surgery, Beijing Cancer Hospital, Peking University, Beijing 100036, P R China
    Ai Zheng 25:100-4. 2006
    ..However, there are still debates on its clinical management. This study was to summarize our experiences in surgical treatment of gastric cardia carcinoma...
  31. ncbi request reprint [Diagnosis and treatment of intralobar pulmonary sequestration]
    Nan Wu
    Department of Thoracic Surgery, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100036, China
    Zhonghua Yi Xue Za Zhi 87:2627-31. 2007
    ..To summarize the diagnosis and surgical treatment of intralobar pulmonary sequestration (PS)...
  32. pmc Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
    Chen Wu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nat Genet 44:1090-7. 2012
    ..Our results underscore the direct genetic contribution to ESCC risk, as well as the genetic contribution to ESCC through interaction with alcohol consumption...
  33. pmc 1A6/DRIM, a novel t-UTP, activates RNA polymerase I transcription and promotes cell proliferation
    Qunhui Peng
    Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
    PLoS ONE 5:e14244. 2010
    ..In this study we have identified 1A6/DRIM, which was identified as UTP20 in our previous study, as a t-UTP. In the present study, we investigated the function and mechanism of 1A6/DRIM in Pol I transcription...
  34. doi request reprint E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6
    Li Zheng
    Beijing Institute for Cancer Research, School of Oncology, Peking University, Beijing 100036, China
    Genes Cells 13:285-94. 2008
    ..The binding regions on E6AP and TSC2 have been identified as amino acid (aa) 260-316, aa 428-500 and aa 1-175, aa 1251-1807, respectively. Taken together, degradation of TSC2 is mediated by E6AP ubiquitin ligase...
  35. ncbi request reprint High level expression and purification of recombinant PEX protein in cultured skeletal muscle cell expression system
    Lin Song
    Department of Cell Biology, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100036, China
    Biochem Biophys Res Commun 357:258-63. 2007
    ..This skeletal muscle cell-based system may be employed for the production of human proteins of special interests, such as those for structural determination or therapeutical development...
  36. ncbi request reprint [Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery]
    Yu Wang
    Typing and Monitoring Laboratory, Beijing Cancer Hospital, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 84:464-8. 2004
    ..To investigate the possibility of utilizing cancer-testi (CT) antigens as targets for immunotherapy of non-small cell lung cancer (NSCLC) with vaccines...