Ming Chang Chiang
Chiang M, Chern Y, Juo C. The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease. Biochim Biophys Acta. 2011;1812:1111-20 pubmed publisher
..These findings show that the impairment of PPAR? contributes to the liver dysfunction observed in HD. Treatment with PPAR? agents (TZD and rosiglitazone) enhanced the function of PPAR?, and might lead to therapeutic benefits. ..
Chiang M, Cheng Y, Chen S, Yen C, Huang R. Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction. Exp Cell Res. 2016;347:322-31 pubmed publisher
..Thus, a better understanding of AMPK might assist in both the recognition of its critical effects and the implementation of new therapeutic strategies in the treatment of AD. ..
Chung M, Nicol C, Cheng Y, Lin K, Chen Y, Pei D, et al
. Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCs. Exp Cell Res. 2017;352:75-83 pubmed publisher
..These findings extend our understanding of the central role of AMPK in AGE induced inflammatory responses, which increase the risk of neurodegeneration in diabetic patients. ..
Lin C, Cheng Y, Nicol C, Lin K, Yen C, Chiang M. Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells. Exp Cell Res. 2017;359:367-373 pubmed publisher
Chiang M, Cheng Y, Nicol C, Lin C. The neuroprotective role of rosiglitazone in advanced glycation end product treated human neural stem cells is PPARgamma-dependent. Int J Biochem Cell Biol. 2017;92:121-133 pubmed publisher
Chiang M, Nicol C, Cheng Y. Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress. Neurochem Int. 2017;: pubmed publisher