Chen L, Liu D, Zhang Y, Zhang H, Cheng H. The autophagy molecule Beclin 1 maintains persistent activity of NF-ÎºB and Stat3 in HTLV-1-transformed T lymphocytes. Biochem Biophys Res Commun. 2015;465:739-45 pubmed publisher
..Our data, therefore, unveiled a key role of Beclin1 in maintaining persistent activities of both NF-ÎºB and Stat3 in the pathogenesis of HTLV-1-mediated oncogenesis. ..
Chen L, Liu D, Zhang Y, Zhang H, Cheng H. Foxp3-dependent transformation of human primary CD4+ T lymphocytes by the retroviral protein tax. Biochem Biophys Res Commun. 2015;466:523-9 pubmed publisher
..Our data, therefore, unveiled a previously unidentified role of Foxp3 in T cell transformation, providing a molecular basis for HTLV-1 transformation of CD4+Foxp3+ T cells. ..
Zhang H, Chen L, Cai S, Cheng H. Identification of TBK1 and IKKÎµ, the non-canonical IÎºB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes. Leuk Res. 2016;46:37-44 pubmed publisher
..Our data, therefore, demonstrate a key role of TBK1/IKKÎµ in the survival and proliferation of HTLV-1-transformed T cells and implicate a potential therapy targeting TBK1/IKKÎµ and Stat3 in controlling HTLV-1-mediated oncogenesis. ..
Niu G, Zhang H, Liu D, Chen L, Belani C, Wang H, et al
. Tid1, the Mammalian Homologue of Drosophila Tumor Suppressor Tid56, Mediates Macroautophagy by Interacting with Beclin1-containing Autophagy Protein Complex. J Biol Chem. 2015;290:18102-10 pubmed publisher
..Together, these results reveal a crucial role of Tid1 as an evolutionarily conserved and essential mediator of canonical macroautophagy. ..