Chatel B, Messonnier L, Vilmen C, Bernard M, Pialoux V, Bendahan D. Exacerbated metabolic changes in skeletal muscle of sickle cell mice submitted to an acute ischemia - reperfusion paradigm. Clin Sci (Lond). 2018;: pubmed publisher
..These metabolic abnormalities could worsen the complications related to the pathology of SCD. ..
Chatel B, Messonnier L, Barge Q, Vilmen C, Noirez P, Bernard M, et al
. Endurance training reduces exercise-induced acidosis and improves muscle function in a mouse model of sickle cell disease. Mol Genet Metab. 2018;123:400-410 pubmed publisher
..05). In conclusion, endurance training would reverse the more pronounced exercise-induced acidosis, reduce oxidative stress and ameliorate some of the muscle function parameters in SCD mice. ..
Chatel B, HourdÃ© C, Gondin J, FourÃ© A, Le Fur Y, Vilmen C, et al
. Impaired muscle force production and higher fatigability in a mouse model of sickle cell disease. Blood Cells Mol Dis. 2017;63:37-44 pubmed publisher
..These changes are independent of muscle mass. Moreover, SCD is associated with muscle fatigability when exercise intensity is high. ..
Chatel B, Bendahan D, Hourde C, Pellerin L, Lengacher S, Magistretti P, et al
. Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice. FASEB J. 2017;31:2562-2575 pubmed publisher
..Lengacher, S., Magistretti, P., Fur, Y. L., Vilmen, C., Bernard, M., Messonnier, L. A. Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice. ..
Chatel B, Messonnier L, HourdÃ© C, Vilmen C, Bernard M, Bendahan D. Moderate and intense muscular exercises induce marked intramyocellular metabolic acidosis in sickle cell disease mice. J Appl Physiol (1985). 2017;122:1362-1369 pubmed publisher
..From that point of view, our results tend to support the idea that high-intensity exercise may increase the risk of hemoglobin polymerization in SCD. ..
Chatel B, Messonnier L, Bendahan D. Exacerbated in vivo metabolic changes suggestive of a spontaneous muscular vaso-occlusive crisis in exercising muscle of a sickle cell mouse. Blood Cells Mol Dis. 2017;65:56-59 pubmed publisher
..However, no evidence of a direct cause-effect relationship between exercise and VOC has been put forth. ..