- NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophreniaAmy J Ramsey
University of Toronto, Department of Pharmacology and Toxicology, Toronto, ON, Canada
Prog Brain Res 179:51-8. 2009..Through the study of these models, our improved understanding of how the brain adapts to persistent NMDA receptor hypofunction may eventually suggest new therapeutic strategies for schizophrenia...
- Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent mannerAmy J Ramsey
Department of Pharmacology and Toxicology, University of Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 108:5795-800. 2011..The synaptic reduction of DISC1 and 14-3-3ε is developmentally correlated with the age-dependent decrease in striatal spine density...