Amy J Ramsey
Affiliation: University of Toronto
- Ramsey A. NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia. Prog Brain Res. 2009;179:51-8 pubmed publisher..Through the study of these models, our improved understanding of how the brain adapts to persistent NMDA receptor hypofunction may eventually suggest new therapeutic strategies for schizophrenia. ..
- Ramsey A, Milenkovic M, Oliveira A, Escobedo Lozoya Y, Seshadri S, Salahpour A, et al. Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proc Natl Acad Sci U S A. 2011;108:5795-800 pubmed publisher..The synaptic reduction of DISC1 and 14-3-3ε is developmentally correlated with the age-dependent decrease in striatal spine density. ..