Amy J Ramsey
Affiliation: University of Toronto
Ramsey A. NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia. Prog Brain Res. 2009;179:51-8 pubmed publisher
..Through the study of these models, our improved understanding of how the brain adapts to persistent NMDA receptor hypofunction may eventually suggest new therapeutic strategies for schizophrenia. ..
Vecchio L, Bermejo M, Beerepoot P, Ramsey A, Salahpour A. N-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo. Mol Cell Neurosci. 2014;61:123-32 pubmed publisher
Bermejo M, Milenkovic M, Salahpour A, Ramsey A. Preparation of synaptic plasma membrane and postsynaptic density proteins using a discontinuous sucrose gradient. J Vis Exp. 2014;:e51896 pubmed publisher
..Resulting protein preparations are suitable for western blotting or 2D DIGE analysis. ..
Masoud S, Vecchio L, Bergeron Y, Hossain M, Nguyen L, Bermejo M, et al
. Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. Neurobiol Dis. 2015;74:66-75 pubmed publisher
..The effects of increased dopamine uptake in these transgenic mice could shed light on the unique vulnerability of dopamine neurons in Parkinson's disease. ..
Ramsey A, Milenkovic M, Oliveira A, Escobedo Lozoya Y, Seshadri S, Salahpour A, et al
. Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proc Natl Acad Sci U S A. 2011;108:5795-800 pubmed publisher
..The synaptic reduction of DISC1 and 14-3-3? is developmentally correlated with the age-dependent decrease in striatal spine density. ..