Richard Leigh

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma
    Chad K Oh
    MedImmune, One MedImmune Way, Gaithersburg, MD, USA
    Respir Res 14:93. 2013
  2. pmc Omalizumab: Practical considerations regarding the risk of anaphylaxis
    Harold L Kim
    University of Western Ontario, London, Ontario, Canada and McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Clin Immunol 6:32. 2010
  3. doi request reprint Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling
    Richard Leigh
    Airway Inflammation Research Group, Department of Medicine, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    J Allergy Clin Immunol 121:1238-1245.e4. 2008
  4. doi request reprint Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells
    Neil S Holden
    Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada N S H, T G, C F R, A C, S S, M K, R L, M A G, R N GlaxoSmithKline Research and Development, Uxbridge, Middlesex, United Kingdom M J and Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia D P S
    J Pharmacol Exp Ther 348:12-24. 2014
  5. doi request reprint Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone
    Claire E Tacon
    Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, Department of Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada
    J Immunol 188:4621-30. 2012
  6. doi request reprint Epithelial cells and airway diseases
    David Proud
    Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada
    Immunol Rev 242:186-204. 2011
  7. doi request reprint Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B
    Claire E Tacon
    Department of Medicine, Snyder Institute of Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    Am J Respir Cell Mol Biol 43:201-9. 2010
  8. pmc Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes
    David Proud
    Airway Inflammation Research Group, Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
    PLoS ONE 7:e40762. 2012
  9. pmc Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration
    Sara E Hartmann
    Dept of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
    ERJ Open Res 1:. 2015
  10. pmc Cerebrovascular Responsiveness to Hypercapnia Is Stable over Six Months in Older Adults
    Matthew D Spencer
    Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1 Canada
    PLoS ONE 10:e0143059. 2015

Collaborators

Detail Information

Publications45

  1. pmc A randomized, controlled trial to evaluate the effect of an anti-interleukin-9 monoclonal antibody in adults with uncontrolled asthma
    Chad K Oh
    MedImmune, One MedImmune Way, Gaithersburg, MD, USA
    Respir Res 14:93. 2013
    ..The aim of this study was therefore to evaluate the effects of MEDI-528, an anti-interleukin-9 monoclonal antibody, in adults with confirmed uncontrolled moderate-to-severe asthma...
  2. pmc Omalizumab: Practical considerations regarding the risk of anaphylaxis
    Harold L Kim
    University of Western Ontario, London, Ontario, Canada and McMaster University, Hamilton, Ontario, Canada
    Allergy Asthma Clin Immunol 6:32. 2010
    ....
  3. doi request reprint Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling
    Richard Leigh
    Airway Inflammation Research Group, Department of Medicine, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    J Allergy Clin Immunol 121:1238-1245.e4. 2008
    ..We reasoned that HRV infections might be important in the pathogenesis of airway remodeling, thereby providing a mechanism by which these children are at risk of asthma...
  4. doi request reprint Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells
    Neil S Holden
    Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada N S H, T G, C F R, A C, S S, M K, R L, M A G, R N GlaxoSmithKline Research and Development, Uxbridge, Middlesex, United Kingdom M J and Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia D P S
    J Pharmacol Exp Ther 348:12-24. 2014
    ..Thus, RGS2 expression is a novel effector mechanism in the airway epithelium that is induced by glucocorticoid/LABA combinations. This could contribute to the efficacy of glucocorticoid/LABA combinations in asthma and COPD. ..
  5. doi request reprint Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone
    Claire E Tacon
    Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, Department of Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada
    J Immunol 188:4621-30. 2012
    ..Together, these results offer insights into the mechanisms by which long-acting β(2)-agonists and glucocorticoids might reduce HRV-related asthma exacerbations...
  6. doi request reprint Epithelial cells and airway diseases
    David Proud
    Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada
    Immunol Rev 242:186-204. 2011
    ..Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function...
  7. doi request reprint Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B
    Claire E Tacon
    Department of Medicine, Snyder Institute of Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    Am J Respir Cell Mol Biol 43:201-9. 2010
    ..This increase in MMP-9 may be a mechanism by which rhinovirus infections contribute to airway inflammation and, potentially, to airway remodeling...
  8. pmc Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes
    David Proud
    Airway Inflammation Research Group, Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
    PLoS ONE 7:e40762. 2012
    ..These changes were not associated with altered expression of type I or type III interferons. Thus, CSE alters epithelial responses to HRV infection in a manner that may negatively impact antiviral and host defense outcomes...
  9. pmc Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration
    Sara E Hartmann
    Dept of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
    ERJ Open Res 1:. 2015
    ..05). Vitamin C increases the ventilatory but not cerebrovascular response to hyperoxic hypercapnia in patients with moderate COPD...
  10. pmc Cerebrovascular Responsiveness to Hypercapnia Is Stable over Six Months in Older Adults
    Matthew D Spencer
    Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1 Canada
    PLoS ONE 10:e0143059. 2015
    ..Modest changes in MCAv over time must be viewed in the context of underlying differences in PETCO2, an important finding with implications for future studies considering cerebral blood flow velocity. ..
  11. pmc β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids
    Neil S Holden
    Airways Inflammation Research Group, Faculty of Medicine, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 108:19713-8. 2011
    ....
  12. doi request reprint Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 138:1051-1059. 2016
    ..Omalizumab is an established anti-IgE therapy for the treatment of allergic diseases that prevents IgE from binding to its receptor. QGE031 is an investigational anti-IgE antibody that binds IgE with higher affinity than omalizumab...
  13. doi request reprint Blood Flow during Handgrip Exercise in COPD: Effect of Vitamin C
    Sara E Hartmann
    1Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, CANADA 2Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, CANADA 3Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada 4Department of Medicine, University of Calgary, Calgary, Alberta, CANADA 5Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, CANADA 6Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, CANADA 7Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, CANADA 8Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, CANADA and 9Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada
    Med Sci Sports Exerc 48:200-9. 2016
    ..We tested if brachial blood flow (BBF) was reduced during handgrip exercise in COPD and if this response would be improved after vitamin C infusion...
  14. doi request reprint Effects of an anti-TSLP antibody on allergen-induced asthmatic responses
    Gail M Gauvreau
    From the Firestone Institute of Respiratory Health, Department of Medicine, McMaster University, Hamilton, ON G M G, P M O, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec City, QC L P B, Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, SK D C, B E D, Institute for Heart and Lung Health, University of British Columbia, Vancouver J M F, and Snyder Institute for Chronic Diseases, Faculty of Medicine, Calgary, AB R L all in Canada Amgen, Thousand Oaks, CA Y W, M B, C D, K S G, L S, E B, J R P and Amgen, Seattle J B, M R C
    N Engl J Med 370:2102-10. 2014
    ..AMG 157 is a human anti-TSLP monoclonal immunoglobulin G2λ that binds human TSLP and prevents receptor interaction...
  15. doi request reprint Decreased cerebrovascular response to CO2 in post-menopausal females with COPD: role of oxidative stress
    Sara E Hartmann
    Faculty of Medicine, University of Calgary, Calgary, ABT2N 4N1, Canada
    Eur Respir J 40:1354-61. 2012
    ..Our results suggest that increased levels of systemic oxidative stress may have implications in the cerebrovascular dysfunction observed during hypercapnia in COPD...
  16. doi request reprint Use of biologicals as immunotherapy in asthma and related diseases
    Brandie L Walker
    Airway Inflammation Research Group, Department of Medicine, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, AB, Canada
    Expert Rev Clin Immunol 4:743-56. 2008
    ..The purpose of this review is to summarize the data from these studies and to provide a rationale for the use of these compounds in asthma and related allergic airway diseases...
  17. doi request reprint Effect of the management of patients with chronic cough by pulmonologists and certified respiratory educators on quality of life: a randomized trial
    Stephen K Field
    Calgary COPD and Asthma Program and Division of Respirology, Calgary Health Region, The University of Calgary, Calgary, AB, Canada
    Chest 136:1021-8. 2009
    ..This study was undertaken to see whether CREs could assist pulmonologists (MDs) in managing patients with chronic cough...
  18. doi request reprint Mometasone furoate: an inhaled glucocorticoid for the management of asthma in adults and children
    Robert L Cowie
    Faculty of Medicine, University of Calgary, Institute of Infection, Immunity and Inflammation, Department of Medicine, 3280 Hospital Drive NW, Calgary, Alberta, Canada
    Expert Opin Pharmacother 10:2009-14. 2009
    ..These effects are minimal when mometasone is used appropriately at low or moderate doses...
  19. ncbi request reprint Eosinophilic bronchitis in asthma: a model for establishing dose-response and relative potency of inhaled corticosteroids
    Margaret M Kelly
    Airways Research Group, Firestone Institute for Respiratory Health, Hamilton, Canada
    J Allergy Clin Immunol 117:989-94. 2006
    ..Newer generations and formulations of inhaled corticosteroids have necessitated the development of a clinically relevant model to compare their clinical potency...
  20. doi request reprint Chemokine release from human rhinovirus-infected airway epithelial cells promotes fibroblast migration
    Christopher Shelfoon
    Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Allergy Clin Immunol 138:114-122.e4. 2016
    ..We hypothesized that HRV-infected epithelial cells release chemoattractants to recruit fibroblasts that could potentially contribute to thickening of the lamina reticularis...
  21. doi request reprint Cerebrovascular and ventilatory responses to acute isocapnic hypoxia in healthy aging and lung disease: effect of vitamin C
    Sara E Hartmann
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada and
    J Appl Physiol (1985) 119:363-73. 2015
    ..e., cerebrovascular and ventilatory) during acute hypoxemia in healthy older adults. Vitamin C does not appear to have a large influence on the cerebrovascular or ventilatory responses during acute hypoxia. ..
  22. ncbi request reprint Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors
    Robert Newton
    Department of Cell Biology and Anatomy, Respiratory Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Pharmacol Exp Ther 321:734-42. 2007
    ....
  23. doi request reprint Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases
    Robert Newton
    Department of Cell Biology and Anatomy, Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Pharmacol Ther 125:286-327. 2010
    ..In this review, we discuss pharmacological methods by which selective GR modulators and "add-on" therapies may be exploited to improve the clinical efficacy of glucocorticoids while reducing potential adverse effects...
  24. doi request reprint Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma
    Margaret M Kelly
    Firestone Institute for Respiratory Health, Department of Medicine, St Joseph s Healthcare and McMaster University Medical Center, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Allergy Clin Immunol 125:349-356.e13. 2010
    ..However, there are limited data as to whether these beneficial effects are due to enhanced anti-inflammatory actions or whether such combination therapies affect airway remodeling in patients with asthma...
  25. pmc Cerebrovascular responses to submaximal exercise in women with COPD
    Sara E Hartmann
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    BMC Pulm Med 14:99. 2014
    ..We hypothesized that COPD patients would have lower cerebral blood flow during exercise secondary to decreased physical fitness and underlying vascular disease...
  26. pmc The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
    Amanda V Tyndall
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    BMC Geriatr 13:21. 2013
    ....
  27. doi request reprint Effect of incremental exercise on airway and systemic inflammation in patients with COPD
    Warren J Davidson
    Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Appl Physiol (1985) 112:2049-56. 2012
    ..However, there was also a reduction in sputum proinflammatory cytokines, suggesting some anti-inflammatory effect of exercise in the lungs of steroid-naïve patients with COPD...
  28. doi request reprint Virus-induced modulation of lower airway diseases: pathogenesis and pharmacologic approaches to treatment
    Richard Leigh
    Airway Inflammation Research Group, Snyder Institute for Chronic Diseases and Department of Medicine, University of Calgary Faculty of Medicine, Calgary, Canada Airway Inflammation Research Group, Snyder Institute for Chronic Diseases and Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, Canada
    Pharmacol Ther 148:185-98. 2015
    ....
  29. pmc The impact of diurnal variation on induced sputum cell counts in healthy adults
    Warren J Davidson
    Department of Medicine, University of Calgary, 7007 14th Street SW, Calgary, Alberta, T2V 1P9, Canada
    Clin Transl Allergy 3:8. 2013
    ..The objective of this study was to describe the diurnal variation in induced sputum cell counts, compared between early morning and late afternoon, in healthy adult individuals...
  30. doi request reprint Ventilatory responses to exercise and CO2 after menopause in healthy women: effects of age and fitness
    Margie H Davenport
    Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Respir Physiol Neurobiol 184:1-8. 2012
    ..8±11.5; OPM: 34.8±6.9, p<0.01) which may be explained, at least in part, by age-related declines in lung function. HCVR and ΔV˙(E)/ΔV˙CO2 were not correlated...
  31. ncbi request reprint Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 169:860-7. 2004
    ..Our results confirm that IL-4 and IL-13, but not IL-5, are critical for the development of sustained airway hyperreactivity and airway remodeling after allergen exposure...
  32. doi request reprint Effect of cardiorespiratory fitness on vascular regulation and oxidative stress in postmenopausal women
    Vincent Pialoux
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Hypertension 54:1014-20. 2009
    ..Furthermore, these results suggest that oxidative stress and NO production modulate MABP and CVC...
  33. ncbi request reprint T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Appl Physiol 97:2258-65. 2004
    ..These results indicate that T-cell-mediated inflammation is critical for development of AHR associated with brief allergen exposure, but is not necessary to maintain sustained AHR...
  34. pmc Smoking, season, and detection of Chlamydia pneumoniae DNA in clinically stable COPD patients
    Marek Smieja
    Department of Pathology and Molecular Medicine, St Joseph s Healthcare and McMaster University, Hamilton ON Canada
    BMC Infect Dis 2:12. 2002
    ..The prevalence and role of Chlamydia pneumoniae in chronic obstructive pulmonary disease (COPD) remain unclear, and molecular methods of detection may help clarify this relationship...
  35. ncbi request reprint Safety of sputum induction in moderate-to-severe smoking-related chronic obstructive pulmonary disease
    Andrew M Wilson
    School of Medicine Health Policy and Practice, University of East Anglia, UK
    COPD 3:89-93. 2006
    ..Investigation of the safety of sputum induction in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) has been limited...
  36. ncbi request reprint Effect of interferon-gamma on allergic airway responses in interferon-gamma-deficient mice
    Makoto Yoshida
    Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario, L8N 4A6 Canada
    Am J Respir Crit Care Med 166:451-6. 2002
    ..Observations that IFN-gamma reverses airway responses, even when administered after challenge, suggests that IFN-gamma treatment could control allergic disease, including asthma...
  37. ncbi request reprint Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation
    Richard Leigh
    Firestone Institute for Respiratory Health, Department of Medicine and Center for Gene Therapeutics, Hamilton, Ontario, Canada
    Am J Respir Cell Mol Biol 27:526-35. 2002
    ....
  38. ncbi request reprint Morphometric analysis of mouse airways after chronic allergen challenge
    Russ Ellis
    Firestone Institute for Respiratory Health and Department of Medicine, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Lab Invest 83:1285-91. 2003
    ..This morphometric technique provides a valid and objective method to assess structural changes in the airways of mice after chronic allergen exposure...
  39. ncbi request reprint Cell-specific gene expression in patients with usual interstitial pneumonia
    Margaret M Kelly
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Am J Respir Crit Care Med 174:557-65. 2006
    ..Usual interstitial pneumonia (UIP) is characterized by extracellular matrix deposition and the development of pulmonary fibrosis. Fibroblastic foci found in the lung are believed to represent an early stage in the evolution of this disease...
  40. ncbi request reprint Epithelial expression of profibrotic mediators in a model of allergen-induced airway remodeling
    Margaret M Kelly
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, MDCL 4017, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada
    Am J Respir Cell Mol Biol 32:99-107. 2005
    ..These data suggest that transforming growth factor-beta1 and other profibrotic mediators produced by airway wall, and specifically, airway epithelium, play an important role in the pathophysiology of airway remodeling...
  41. ncbi request reprint Effects of montelukast and budesonide on airway responses and airway inflammation in asthma
    Richard Leigh
    Asthma Research Group, Firestone Institute for Respiratory Health and Department of Medicine, St Joseph s Healthcare McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 166:1212-7. 2002
    ....
  42. ncbi request reprint Clinical models to compare the safety and efficacy of inhaled corticosteroids in patients with asthma
    Krishnan Parameswaran
    Asthma Research Group, Firestone Institute of Respiratory Health, St Joseph s Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario
    Can Respir J 10:27-34. 2003
    ....
  43. ncbi request reprint Change in forced expiratory volume in 1 second after sham bronchoconstrictor in suggestible but not suggestion-resistant asthmatic subjects: a pilot study
    Richard Leigh
    Firestone Institute for Respiratory Health R L, F E H and the Brain Body Institute G M, G T, J B, St Joseph s Healthcare, McMaster University, Hamilton, Ontario, Canada
    Psychosom Med 65:791-5. 2003
    ..Literature points to the importance of suggestion in asthma, and we reasoned that patients' level of suggestibility might influence their likelihood of responding to placebo-like suggestion...
  44. ncbi request reprint Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice?
    Richard Leigh
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario L8N 4A6, Canada
    Am J Respir Crit Care Med 170:851-6. 2004
    ....
  45. ncbi request reprint Effects of acetazolamide on ventilatory, cerebrovascular, and pulmonary vascular responses to hypoxia
    Luc J Teppema
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 175:277-81. 2007
    ..Acetazolamide is effective against AMS, possibly by increasing ventilation and cerebral blood flow (CBF). In animals, it inhibits hypoxic pulmonary vasoconstriction...