I W Fong
Affiliation: St. Michael's Hospital
- Chlamydia pneumoniae and Cardiovascular DiseaseMaria Kolia
Division of Infectious Disease, St Michael s Hospital, 30 Bond Street, Room 4179V, Toronto, Ontario, M5W 1W8, Canada
Curr Infect Dis Rep 4:35-43. 2002..Better diagnostic tools, more diverse animal models, and clinical trials of primary prevention are needed. Meanwhile, results of ongoing large clinical trials on secondary prevention are eagerly awaited, but may not be definitive...
- New perspectives of infections in cardiovascular diseaseIgnatius W Fong
University of Toronto, Division of Infectious Diseases, St Michaels Hospital, 4CC 179 Cardinal Carter Wing, 30 Bond St, Toronto, Ontario, M5B 1W8, Canada
Curr Cardiol Rev 5:87-104. 2009....
- Influence of clarithromycin on early atherosclerotic lesions after Chlamydia pneumoniae infection in a rabbit modelIgnatius W Fong
Department of Medicine, Division of Infectious Disease, St Michael s Hospital and University of Toronto, 30 Bond Street, Rm 4 179C, Toronto, M5B 1W8 Ontario, Canada
Antimicrob Agents Chemother 46:2321-6. 2002..Thus, clarithromycin administration modified C. pneumoniae-induced atherosclerotic lesions and reduced the ability to detect organism in tissue. Early treatment was more effective than delayed treatment...
- Chlamydial heat-shock protein-60 antibody and correlation with Chlamydia pneumoniae in atherosclerotic plaquesIgnatius W Fong
Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
J Infect Dis 186:1469-73. 2002..pneumoniae antigen, versus 5.7+/-6.1 mg/L in those without (P=.556). Immune response to CHSP-60 may play a role in atherogenesis, but CRP serum levels does not appear to be related to C. pneumoniae infection...
- Emerging relations between infectious diseases and coronary artery disease and atherosclerosisI W Fong
Department of Medicine, St Michael s Hospital, Toronto, Ont
CMAJ 163:49-56. 2000..The results of large randomized clinical trials in progress will help establish causality and the benefits of antimicrobial therapy in CAD...
- Antibiotics effects in a rabbit model of Chlamydia pneumoniae-induced atherosclerosisI W Fong
Division of Infectious Diseases, St Michael s Hospital, Toronto, Ontario M5B 1W8, Canada
J Infect Dis 181:S514-8. 2000..These studies support but do not prove that C. pneumoniae can cause atherosclerosis. Antibiotics are potentially useful in this model, but the optimum dose and duration of therapy or use of combination of agents remain to be determined...
- Value of long-term administration of acyclovir and similar agents for protecting against AIDS-related lymphoma: case-control and historical cohort studiesI W Fong
Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
Clin Infect Dis 30:757-61. 2000..002). Long-term administration (>1 year) of high-dose acyclovir or similar agents with anti-EBV activity may prevent NHL in patients with AIDS. A prospective, randomized study is warranted to confirm these results...
- Can an antibiotic (macrolide) prevent Chlamydia pneumoniae-induced atherosclerosis in a rabbit model?I W Fong
Departments of Medicine, Laboratory Medicine and Pathology, St Michael s Hospital, University of Toronto, Toronto, Canada
Clin Diagn Lab Immunol 6:891-4. 1999..It is possible that longer or more aggressive antibiotic treatment may be needed to reverse preformed lesions or that antibiotics may not be of value once lesions have formed...
- Value of animal models for Chlamydia pneumoniae-related atherosclerosisI W Fong
Department of Medicine, University of Toronto, Canada
Am Heart J 138:S512-3. 1999..An effective vaccine for prevention of C pneumoniae -induced pneumonia and possibly atherosclerotic lesions in human beings would have tremendous application and would circumvent the shortcomings of antibiotic therapy...
- De Novo induction of atherosclerosis by Chlamydia pneumoniae in a rabbit modelI W Fong
Departments of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
Infect Immun 67:6048-55. 1999..pneumoniae. These data are compatible with de novo induction of atherogenesis by C. pneumoniae in rabbits and suggest that C. pneumoniae may be important in the pathogenesis of atherosclerosis in humans...
- Infections and their role in atherosclerotic vascular diseaseIgnatius W Fong
St Michael s Hospital, Department of Medicine, University of Toronto, 30 Bond St, Room 4 179V, Toronto, Ontario, M5B 1W8 Canada
J Am Dent Assoc 133:7S-13S. 2002..Complications of atherosclerosis are the leading cause of mortality in developed countries, and infections may play a role in the pathogenesis. Numerous studies have addressed this issue in the past decade...
- Integrative aspects of a human model of endotoxemiaC A Ottaway
Department of Medicine, St Michael s Hospital, University of Toronto, ON, Canada
Can J Physiol Pharmacol 76:473-8. 1998....
- Impact of treating Staphylococcus aureus nasal carriers on wound infections in cardiac surgeryA Konvalinka
Division of Internal Medicine, University of Toronto, Toronto, Ontario, Canada
J Hosp Infect 64:162-8. 2006..Prophylactic intranasal mupirocin administered to S. aureus carriers did not reduce the rates of overall surgical site infections by S. aureus, and only showed a trend towards decreased incidence of nosocomial S. aureus infections...
- Transfusion-transmitted babesiosis in Ontario: first reported case in CanadaK C Kain
Centre for Travel and Tropical Medicine, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ont
CMAJ 164:1721-3. 2001..Prompt recognition and treatment are important, because Babesia infections can be severe or fatal in certain risk groups. Better strategies to prevent transfusion-transmitted babesiosis are required...
- Chlamydia pneumoniae infection of endothelial cells induces transcriptional activation of platelet-derived growth factor-B: a potential link to intimal thickening in a rabbit model of atherosclerosisBrian K Coombes
Department of Medical Sciences, Father Sean O Sullivan Research Centre, McMaster University, St Joseph s Hospital, 50 Charlton Avenue East, Hamilton, Ontario, Canada L8N 4A6
J Infect Dis 185:1621-30. 2002..009). These results suggest that C. pneumoniae-induced SMC proliferation and intimal thickening may be mediated through PDGF-B and may be a molecular mechanism by which C. pneumoniae infection could contribute to atherogenesis...