Genomes and Genes

Species

R Rozen

Summary

Affiliation: McGill University
Country: Canada

Publications

  1. Jadavji N, Deng L, Malysheva O, Caudill M, Rozen R. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. 2015;300:1-9 pubmed publisher
    ..We suggest that deficiencies in maternal one-carbon metabolism during pregnancy can contribute to hippocampal dysfunction in offspring through apoptosis or altered choline metabolism. ..
  2. request reprint
    Christensen K, Hou W, Bahous R, Deng L, Malysheva O, Arning E, et al. Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. Am J Clin Nutr. 2016;104:1459-1469 pubmed
    ..These findings have implications for women with high folate intakes, particularly if they are polymorphic for MTHFD1 R653Q. ..

Detail Information

Publications2

  1. Jadavji N, Deng L, Malysheva O, Caudill M, Rozen R. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. 2015;300:1-9 pubmed publisher
    ..We suggest that deficiencies in maternal one-carbon metabolism during pregnancy can contribute to hippocampal dysfunction in offspring through apoptosis or altered choline metabolism. ..
  2. request reprint
    Christensen K, Hou W, Bahous R, Deng L, Malysheva O, Arning E, et al. Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. Am J Clin Nutr. 2016;104:1459-1469 pubmed
    ..These findings have implications for women with high folate intakes, particularly if they are polymorphic for MTHFD1 R653Q. ..