Affiliation: McGill University
- Jadavji N, Deng L, Malysheva O, Caudill M, Rozen R. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. 2015;300:1-9 pubmed publisher..We suggest that deficiencies in maternal one-carbon metabolism during pregnancy can contribute to hippocampal dysfunction in offspring through apoptosis or altered choline metabolism. ..
- Christensen K, Hou W, Bahous R, Deng L, Malysheva O, Arning E, et al. Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. Am J Clin Nutr. 2016;104:1459-1469 pubmed..These findings have implications for women with high folate intakes, particularly if they are polymorphic for MTHFD1 R653Q. ..