Affiliation: McGill University
Bahous R, Cosín Tomás M, Deng L, Leclerc D, Malysheva O, Ho M, et al
. Early Manifestations of Brain Aging in Mice Due to Low Dietary Folate and Mild MTHFR Deficiency. Mol Neurobiol. 2018;: pubmed publisher
..These findings shed further insights into the mechanisms by which genetic and dietary folate metabolic disturbances increase the risk for cognitive decline and suggest that these mechanisms are distinct. ..
Christensen K, Dahhou M, Kramer M, Rozen R. The MTHFD1 1958G>A variant is associated with elevated C-reactive protein and body mass index in Canadian women from a premature birth cohort. Mol Genet Metab. 2014;111:390-392 pubmed publisher
..Increases in the inflammatory marker CRP (logistic regression, p = 0.055) and BMI (chi-square, p = 0.0113) were associated with AA genotype in women with low folate. MTHFD1 1958G>A may influence immune function and obesity. ..
Leclerc D, Lévesque N, Cao Y, Deng L, Wu Q, Powell J, et al
. Genes with aberrant expression in murine preneoplastic intestine show epigenetic and expression changes in normal mucosa of colon cancer patients. Cancer Prev Res (Phila). 2013;6:1171-81 pubmed publisher
LÃ©vesque N, Leclerc D, Gayden T, Lazaris A, De Jay N, Petrillo S, et al
. Murine diet/tissue and human brain tumorigenesis alter Mthfr/MTHFR 5'-end methylation. Mamm Genome. 2016;27:122-34 pubmed publisher
Jadavji N, Deng L, Malysheva O, Caudill M, Rozen R. MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring. Neuroscience. 2015;300:1-9 pubmed publisher
..We suggest that deficiencies in maternal one-carbon metabolism during pregnancy can contribute to hippocampal dysfunction in offspring through apoptosis or altered choline metabolism. ..
Christensen K, Hou W, Bahous R, Deng L, Malysheva O, Arning E, et al
. Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. Am J Clin Nutr. 2016;104:1459-1469 pubmed
..These findings have implications for women with high folate intakes, particularly if they are polymorphic for MTHFD1 R653Q. ..