D M Skowronski
Affiliation: British Columbia
Skowronski D, De Serres G. Is routine influenza immunization warranted in early pregnancy?. Vaccine. 2009;27:4754-70 pubmed publisher
..Evidence is otherwise insufficient to recommend routine TIV as the standard of practice for all healthy women beginning in early pregnancy. ..
Skowronski D, Hottes T, Janjua N, Purych D, Sabaiduc S, Chan T, et al
. Prevalence of seroprotection against the pandemic (H1N1) virus after the 2009 pandemic. CMAJ. 2010;182:1851-6 pubmed publisher
..These findings, particularly the low levels of seroprotection among people aged 50-79 years, should be confirmed in other settings and closer to the influenza season. ..
Skowronski D, Hamelin M, Janjua N, De Serres G, Gardy J, Rhéaume C, et al
. Cross-lineage influenza B and heterologous influenza A antibody responses in vaccinated mice: immunologic interactions and B/Yamagata dominance. PLoS ONE. 2012;7:e38929 pubmed publisher
Skowronski D, Janjua N, De Serres G, Purych D, Gilca V, Scheifele D, et al
. Cross-reactive and vaccine-induced antibody to an emerging swine-origin variant of influenza A virus subtype H3N2 (H3N2v). J Infect Dis. 2012;206:1852-61 pubmed publisher
..Recent formulations of TIV do not substantially increase seroprotection. A specific vaccine would be needed if H3N2v establishes epidemic spread. NCT01140009 and NCT01368796. ..
Skowronski D, Moser F, Janjua N, Davoudi B, English K, Purych D, et al
. H3N2v and other influenza epidemic risk based on age-specific estimates of sero-protection and contact network interactions. PLoS ONE. 2013;8:e54015 pubmed publisher
..However risk assessment may change with time and depends crucially upon the validation of epidemiological features of influenza, notably the serologic correlate of protection and R(0). ..
Porgo T, Gilca V, De Serres G, Tremblay M, Skowronski D. Dramatic reduction in hepatitis B through school-based immunization without a routine infant program in a low endemicity region. BMC Infect Dis. 2015;15:227 pubmed publisher
..The oldest cohorts targeted by catch-up campaigns are now beyond the average age at childbirth so that neo-natal transmission and the potential incremental benefit of infant immunization will likely further diminish. ..
Skowronski D, De Serres G, Crowcroft N, Janjua N, Boulianne N, Hottes T, et al
. Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med. 2010;7:e1000258 pubmed publisher
..The occurrence of bias (selection, information) or confounding cannot be ruled out. Further experimental and epidemiological assessment is warranted. Possible biological mechanisms and immunoepidemiologic implications are considered. ..
Skowronski D, Pielak K, Remple V, Halperin B, Patrick D, Naus M, et al
. Adult tetanus, diphtheria and pertussis immunization: knowledge, beliefs, behavior and anticipated uptake. Vaccine. 2004;23:353-61 pubmed
..These factors may be relevant as immunization programs are expanded to include more adults generally. ..
Skowronski D, De Serres G, Dickinson J, Petric M, Mak A, Fonseca K, et al
. Component-specific effectiveness of trivalent influenza vaccine as monitored through a sentinel surveillance network in Canada, 2006-2007. J Infect Dis. 2009;199:168-79 pubmed publisher
..Sentinel surveillance provides a broad platform to link new variant detection and the composite of circulating viruses to annual monitoring of component-specific VE. ..