Potje S, Munhoz F, Perassa L, Graton M, Pereira A, Nakamune A, et al
. Mechanisms underlying the hypotensive and vasodilator effects of Ru(terpy)(bdq)NO](3+), a nitric oxide donor, differ between normotensive and spontaneously hypertensive rats. Eur J Pharmacol. 2014;741:222-9 pubmed publisher
..Furthermore, the nitric oxide released by TERPY reacts with reactive oxygen species, decreasing their bioavailability in spontaneously hypertensive rats. ..
Zancheta D, Troiano J, Potje S, Cavalari P, Sumida D, Antoniali C. The PI3K-Akt-eNOS pathway is involved in aortic hyporeactivity to Phenylephrine associated with late pregnancy in spontaneously hypertensive rats. Life Sci. 2015;122:78-86 pubmed publisher
..The PI3/AKT/endothelial nitric oxide synthase (eNOS) pathway contributes to aortic hyporeactivity to Phenylephrine associated with pregnancy in normo- and hypertensive rats. ..
Potje S, Troiano J, Grando M, Graton M, da Silva R, Bendhack L, et al
. Endothelial modulation of a nitric oxide donor complex-induced relaxation in normotensive and spontaneously hypertensive rats. Life Sci. 2018;201:130-140 pubmed publisher
Silva P, Troiano J, Nakamune A, Pessan J, Antoniali C. Increased activity of the antioxidants systems modulate the oxidative stress in saliva of toddlers with early childhood caries. Arch Oral Biol. 2016;70:62-66 pubmed publisher
..Oxidative stress levels were significantly lower in saliva of S-ECC children, what might be associated with the increased activity of salivary enzymatic (SOD) and non-enzymatic (uric acid) antioxidant systems. ..
Troiano J, Potje S, Graton M, Cavalari P, Pereira A, Vale G, et al
. Decreased reactive oxygen species production and NOX1, NOX2, NOX4 expressions contribute to hyporeactivity to phenylephrine in aortas of pregnant SHR. Life Sci. 2016;144:178-84 pubmed publisher
..Taken together, these results suggest that ROS production was decreased in the aortas of pregnant SHR and could contribute to higher NO bioavailability and hyporeactivity to PE in the aortas of pregnant SHR. ..
Perassa L, Graton M, Potje S, Troiano J, Lima M, Vale G, et al
. Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR. Vascul Pharmacol. 2016;87:38-48 pubmed publisher
..Based on all the results presented in this study, we suggest apocynin increases NO biovailability by different mechanisms, restoring the proper function of vascular endothelium in SHR. ..
Potje S, Troiano J, Graton M, Ximenes V, Nakamune A, Antoniali C. Hypotensive and vasorelaxant effect of Diapocynin in normotensive rats. Free Radic Biol Med. 2017;106:148-157 pubmed publisher
Potje S, Chen Z, Oliveira S, Bendhack L, da Silva R, Bonini M, et al
. Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production. Free Radic Biol Med. 2017;112:587-596 pubmed publisher
..Endothelium-dependent vasodilation in response to NO donor TERPY is associated with eNOS activation and uncoupling, and thereby appears to be mediated, at least in part, via eNOS-dependent ROS/RNS production. ..