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..b>Significance: MEK1 inhibitor-resistant colorectal cancer relies on the scaffold and endosomal protein CEMIP to maintain ERK1/2 signaling and Myc-driven transcription. Cancer Res; 78(16); 4533-48. ©2018 AACR. ..
Shostak K, Chariot A. EGFR and NF-ÎºB: partners in cancer. Trends Mol Med. 2015;21:385-93 pubmed publisher
..We review molecular mechanisms by which both EGFR- and NF-ÎºB-dependent pathways establish positive loops to increase their oncogenic potential. We also describe how NF-ÎºB promotes resistance to EGFR inhibitors. ..
Chariot A. The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends Cell Biol. 2009;19:404-13 pubmed publisher
..Thus, these recent findings considerably widen the biological roles of these kinases and suggest that a full understanding of the biological roles of IKK alpha and IKK beta requires an exhaustive characterization of their substrates. ..
Chau T, GÃ¶ktuna S, Rammal A, Casanova T, Duong H, Gatot J, et al
. A role for APPL1 in TLR3/4-dependent TBK1 and IKKÎµ activation in macrophages. J Immunol. 2015;194:3970-83 pubmed publisher
..Those signaling pathways involve the signal-induced degradation of APPL1 to prevent aberrant IRF3-dependent gene expression linked to immune diseases. ..
GÃ¶ktuna S, Shostak K, Chau T, Heukamp L, Hennuy B, Duong H, et al
. The Prosurvival IKK-Related Kinase IKKÎµ Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Res. 2016;76:2587-99 pubmed publisher
..Cancer Res; 76(9); 2587-99. Â©2016 AACR. ..