Rudolf Zechner

Summary

Affiliation: University of Graz
Country: Austria

Publications

  1. Zechner R, Langin D. Hormone-sensitive lipase deficiency in humans. Cell Metab. 2014;20:199-201 pubmed publisher
    ..Albert et al. (2014) demonstrate that the lack of hormone-sensitive lipase, a member of the enzyme trio that catabolizes fat, has pronounced effects on lipid metabolism, glucose homeostasis, and cell signaling in humans. ..
  2. Schreiber R, Hofer P, Taschler U, Voshol P, Rechberger G, Kotzbeck P, et al. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015;112:13850-5 pubmed publisher
    ..These results argue for the existence of an adaptive interdependence between lipolysis and lipid synthesis. Pharmacological inhibition of ATGL may prove useful to prevent HFD-induced obesity and insulin resistance. ..
  3. Zechner R, Zimmermann R, Eichmann T, Kohlwein S, Haemmerle G, Lass A, et al. FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012;15:279-91 pubmed publisher
    ....
  4. Zechner R, Kienesberger P, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 2009;50:3-21 pubmed publisher
    ..This review focuses on the structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL. ..
  5. Schrammel A, Mussbacher M, Winkler S, Haemmerle G, Stessel H, Wölkart G, et al. Cardiac oxidative stress in a mouse model of neutral lipid storage disease. Biochim Biophys Acta. 2013;1831:1600-8 pubmed publisher
    ..Upregulation of soluble guanylate cyclase and cardiac tetrahydrobiopterin might be regarded as counterregulatory mechanisms in cardiac ATGL deficiency. ..
  6. Das S, Stadelmeyer E, Schauer S, Schwarz A, Strohmaier H, Claudel T, et al. Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58. Int J Mol Sci. 2015;16:8555-68 pubmed publisher
    ..Therefore, we suggest that miR-124a may be involved in the regulation of several cellular and organismal metabolic parameters, including lipid storage and plasma FA concentration. ..
  7. Hofer P, Boeszoermenyi A, Jaeger D, Feiler U, Arthanari H, Mayer N, et al. Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling. J Biol Chem. 2015;290:18438-53 pubmed publisher
    ..Our studies identify Fabps as crucial structural and functional components of the lipolysome. ..
  8. Schreiber R, Diwoky C, Schoiswohl G, Feiler U, Wongsiriroj N, Abdellatif M, et al. Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue. Cell Metab. 2017;26:753-763.e7 pubmed publisher
    ..We conclude that functional NST requires adequate substrate supply and cardiac function, but does not depend on ATGL-mediated lipolysis in BAT...

Detail Information

Publications8

  1. Zechner R, Langin D. Hormone-sensitive lipase deficiency in humans. Cell Metab. 2014;20:199-201 pubmed publisher
    ..Albert et al. (2014) demonstrate that the lack of hormone-sensitive lipase, a member of the enzyme trio that catabolizes fat, has pronounced effects on lipid metabolism, glucose homeostasis, and cell signaling in humans. ..
  2. Schreiber R, Hofer P, Taschler U, Voshol P, Rechberger G, Kotzbeck P, et al. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015;112:13850-5 pubmed publisher
    ..These results argue for the existence of an adaptive interdependence between lipolysis and lipid synthesis. Pharmacological inhibition of ATGL may prove useful to prevent HFD-induced obesity and insulin resistance. ..
  3. Zechner R, Zimmermann R, Eichmann T, Kohlwein S, Haemmerle G, Lass A, et al. FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012;15:279-91 pubmed publisher
    ....
  4. Zechner R, Kienesberger P, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 2009;50:3-21 pubmed publisher
    ..This review focuses on the structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL. ..
  5. Schrammel A, Mussbacher M, Winkler S, Haemmerle G, Stessel H, Wölkart G, et al. Cardiac oxidative stress in a mouse model of neutral lipid storage disease. Biochim Biophys Acta. 2013;1831:1600-8 pubmed publisher
    ..Upregulation of soluble guanylate cyclase and cardiac tetrahydrobiopterin might be regarded as counterregulatory mechanisms in cardiac ATGL deficiency. ..
  6. Das S, Stadelmeyer E, Schauer S, Schwarz A, Strohmaier H, Claudel T, et al. Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58. Int J Mol Sci. 2015;16:8555-68 pubmed publisher
    ..Therefore, we suggest that miR-124a may be involved in the regulation of several cellular and organismal metabolic parameters, including lipid storage and plasma FA concentration. ..
  7. Hofer P, Boeszoermenyi A, Jaeger D, Feiler U, Arthanari H, Mayer N, et al. Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling. J Biol Chem. 2015;290:18438-53 pubmed publisher
    ..Our studies identify Fabps as crucial structural and functional components of the lipolysome. ..
  8. Schreiber R, Diwoky C, Schoiswohl G, Feiler U, Wongsiriroj N, Abdellatif M, et al. Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue. Cell Metab. 2017;26:753-763.e7 pubmed publisher
    ..We conclude that functional NST requires adequate substrate supply and cardiac function, but does not depend on ATGL-mediated lipolysis in BAT...