Affiliation: University of Melbourne
- PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanismsJane E Ward
Department of Pharmacology, University of Melbourne, Melbourne, Victoria 3010, Australia
Br J Pharmacol 141:517-25. 2004..British Journal of Pharmacology (2004) 141, 517-525. doi:10.1038/sj.bjp.0705630..
- The PPARgamma ligand, rosiglitazone, reduces airways hyperresponsiveness in a murine model of allergen-induced inflammationJ E Ward
Department of Pharmacology, University of Melbourne, Vic, 3010, Australia
Pulm Pharmacol Ther 19:39-46. 2006..These data suggest that RG modulates AHR in this model, by a mechanism that is also potentially independent of an anti-inflammatory action...
- Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung diseaseJane Elizabeth Ward
Department of Pharmacology, University of Melbourne, Victoria 3010, Australia
PPAR Res 2007:14983. 2007..The activity profiles of PPAR ligands differ to corticosteroids, supporting the hypothesis that PPARs comprise additional therapeutic targets to mimimise the contribution of inflammation to airway remodelling and dysfunction...
- Collagen remodelling by airway smooth muscle is resistant to steroids and β₂-agonistsJ E Bourke
Dept of Pharmacology, University of Melbourne, Victoria, Australia
Eur Respir J 37:173-82. 2011..Therapy-resistant collagen condensation within ASM bundles may facilitate ECM-ASM interactions and contribute to increased internal airways resistance...