Patrick P L Tam
Affiliation: University of Sydney
Tam P, Kanai Azuma M, Kanai Y. Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr Opin Genet Dev. 2003;13:393-400 pubmed
..Morphogenetic interactions between the endoderm and the other germ layer derivatives are critical for the morphogenesis of head structures and organogenesis of gut derivatives. ..
Kinder S, Tsang T, Quinlan G, Hadjantonakis A, Nagy A, Tam P. The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development. 1999;126:4691-701 pubmed
Tam P, Khoo P, Lewis S, Bildsoe H, Wong N, Tsang T, et al
. Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development. 2007;134:251-60 pubmed
..The observation that the endoderm cells are inherently unable to move despite the expansion of the mesoderm in the Mixl1-null mutant suggests that the movement of the endoderm and the mesoderm is driven independently of one another. ..
Tam P, Steiner K. Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo. Development. 1999;126:5171-9 pubmed
..The formation of anterior neural structures therefore requires the synergistic interaction of the early gastrula organizer and anterior germ layer tissues...
Camus A, Davidson B, Billiards S, Khoo P, Rivera Pérez J, Wakamiya M, et al
. The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo. Development. 2000;127:1799-813 pubmed
..The maintenance and function of the rostral AML therefore require inductive signals emanating from the caudal AML. Our results point to a role for AML in the refinement of the anteroposterior patterning and morphogenesis of the brain. ..
Tam P, Khoo P, Wong N, Tsang T, Behringer R. Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function. Dev Biol. 2004;274:171-87 pubmed
..The inefficient movement of the anterior endoderm, and the abnormal differentiation highlighted by the lack of Sox17 and Foxa2 expression, may underpin the malformation of the head of Lhx1 mutant embryos. ..
Tam P, Loebel D, Tanaka S. Building the mouse gastrula: signals, asymmetry and lineages. Curr Opin Genet Dev. 2006;16:419-25 pubmed
..These signalling activities are also required for the specification of anterior and posterior fates of the epiblast cells and for the induction and navigation of the primordial germ cells...
Tam P, Loebel D. Gene function in mouse embryogenesis: get set for gastrulation. Nat Rev Genet. 2007;8:368-81 pubmed