Chee Y Ooi

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. Ooi C, Pang T, Leach S, Katz T, Day A, Jaffe A. Fecal Human β-Defensin 2 in Children with Cystic Fibrosis: Is There a Diminished Intestinal Innate Immune Response?. Dig Dis Sci. 2015;60:2946-52 pubmed publisher
    ..Fecal HBD-2 levels were not increased in children with CF, in inflamed or noninflamed states. The lack of HBD-2 induction and upregulation under inflammatory conditions may suggest a diminished intestinal innate immune response in CF. ..
  2. Sutherland R, Katz T, Liu V, Quintano J, Brunner R, Tong C, et al. Dietary intake of energy-dense, nutrient-poor and nutrient-dense food sources in children with cystic fibrosis. J Cyst Fibros. 2018;: pubmed publisher
    ..This dietary pattern may not be optimal for the future health of children with CF, who are now expected to survive well into adulthood. ..
  3. Williams N, Moriatis M, Chambers G, Ooi C. The role, yield and cost of paediatric faecal elastase-1 testing. Pancreatology. 2016;16:551-4 pubmed publisher
    ..50 (AUD2015) for FTT with short-gut syndrome and $420.00 (AUD2015) for CF-related indications. Our study shows that for patients with isolated failure to thrive, FE1 testing is low yield and costly. ..
  4. Bierma M, Coffey M, Nightingale S, van Rheenen P, Ooi C. Predicting severe acute pancreatitis in children based on serum lipase and calcium: A multicentre retrospective cohort study. Pancreatology. 2016;16:529-34 pubmed publisher
    ..15 mmol/L within 48 h (high specificity) to help predict severe paediatric AP. ..
  5. Sue A, Dehlsen K, Ooi C. Paediatric Patients with Coeliac Disease on a Gluten-Free Diet: Nutritional Adequacy and Macro- and Micronutrient Imbalances. Curr Gastroenterol Rep. 2018;20:2 pubmed publisher
    ..Nutritional inadequacies may be risks of a gluten-free diet in a paediatric population. The potential implications of these inadequacies, both short and long term, remain unclear and warrant further investigation and clarification. ..
  6. Ooi C, Durie P. Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in pancreatitis. J Cyst Fibros. 2012;11:355-62 pubmed publisher
    ..Greater understanding into the underlying mechanisms of disease is much needed. The emergence of CFTR-assist therapies may potentially play a future role in the treatment of CFTR-mutation associated pancreatitis. ..
  7. Duley J, Henman M, Carpenter K, Bamshad M, Marshall G, Ooi C, et al. Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine. Mol Genet Metab. 2016;119:83-90 pubmed publisher
    ..This case resolved the biochemical conundrum in previous reports of Miller syndrome patients, and opened the possibility of rapid biochemical screening. ..
  8. Coffey M, Whitaker V, Gentin N, Junek R, Shalhoub C, Nightingale S, et al. Differences in Outcomes between Early and Late Diagnosis of Cystic Fibrosis in the Newborn Screening Era. J Pediatr. 2017;181:137-145.e1 pubmed publisher
    ..65 vs -0.03; P?=?.02). LD-CF, despite NBS, seems to be associated with worse health before diagnosis and worse later growth and respiratory outcomes, thus providing further support for NBS programs for CF. ..
  9. Garg M, Ooi C. The Enigmatic Gut in Cystic Fibrosis: Linking Inflammation, Dysbiosis, and the Increased Risk of Malignancy. Curr Gastroenterol Rep. 2017;19:6 pubmed publisher
    ..The pathophysiology of interactions among intestinal inflammation, dysbiosis, and malignancy in CF is not clearly understood and requires further research. ..

More Information

Publications11

  1. Garg M, Leach S, Pang T, Needham B, Coffey M, Katz T, et al. Age-related levels of fecal M2-pyruvate kinase in children with cystic fibrosis and healthy children 0 to 10years old. J Cyst Fibros. 2018;17:109-113 pubmed publisher
    ..1] (n=77) vs. 1.0 [1.0-1.0; 1.0-50.0] (n=45) U/mL, respectively; P=0.001). Fecal M2-PK was elevated in children with CF compared with HC during infancy and throughout childhood suggesting abnormalities in the CF gut exist in early life. ..
  2. Garg M, Leach S, Coffey M, Katz T, Strachan R, Pang T, et al. Age-dependent variation of fecal calprotectin in cystic fibrosis and healthy children. J Cyst Fibros. 2017;16:631-636 pubmed publisher
    ..007). Fecal calprotectin levels in children with CF and HC were age-dependent and had distinct trajectories. Careful interpretation of calprotectin is required if used in drug trials for CF, particularly in children less than 4years old. ..