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Genomes and Genes | Rita MachaalaniSummaryAffiliation: University of Sydney Country: Australia Publications
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Publications
Tissue fixation effects on immunohistochemical staining of caspase-3 in brain tissueRita Machaalani
Department of Medicine, The University of Sydney, NSW 2006, Australia
Appl Immunohistochem Mol Morphol 15:463-70. 2007..This study characterizes differences in immunohistochemical outcomes using commercially available antibodies for caspase-3, according to tissue fixation method and species...- Objective adherence to positive airway pressure therapy in an Australian paediatric cohortRita Machaalani
Department of Medicine, University of Sydney, Sydney, NSW, 2006, Australia
Sleep Breath 20:1327-1336. 2016..This study aimed to objectively measure adherence (compliance) and effectiveness of CPAP and BiLevel pressure support in an Australian paediatric population and determine factors associated with adherence outcomes... 
Effects of changes in energy homeostasis and exposure of noxious insults on the expression of orexin (hypocretin) and its receptors in the brainRita Machaalani
Department of Medicine, Blackburn Building, DO6, University of Sydney, NSW 2006, Australia
Brain Res 1526:102-22. 2013....- Distribution of nicotinic acetylcholine receptor subunits alpha7 and beta2 in the human brainstem and hippocampal formationRita Machaalani
Department of Medicine, The University of Sydney, NSW 2006, Australia
J Chem Neuroanat 40:223-31. 2010..We conclude that both alpha7 and beta2 containing nAChRs play an important role in many nuclei of the human infant and adult brainstem, and that the alpha7 subunit may have a more prominent role in the infant than adult hippocampus... - Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factorsRita Machaalani
Department of Medicine, The Bosch Institute, University of Sydney, NSW, Australia
Acta Neuropathol 117:257-65. 2009..This study not only provides further evidence of abnormalities within the brainstem serotoninergic system of SIDS infants, but also shows that these changes may be associated with exposure to clinical risk factors... - Orexin receptors in the developing piglet hypothalamus, and effects of nicotine and intermittent hypercapnic hypoxia exposuresNicholas J Hunt
Department of Pathology, Blackburn Building, DO6, University of Sydney, NSW 2006, Australia
Brain Res 1508:73-82. 2013..IHH induced increases were specific to arousal and stress related regions and nic+IHH results suggest that for OxR1, nicotine has no additive effect whereas for OxR2 it does, and is region dependent... - The effects of nicotine on the alpha-7 and beta-2 nicotinic acetycholine receptor subunits in the developing piglet brainstemCherylea J Browne
Department of Pathology, University of Sydney, NSW 2006, Australia
Int J Dev Neurosci 28:1-7. 2010..Changes in beta2 were more widespread but showed gender-specific effects. These findings provide evidence that early postnatal exposure to nicotine significantly affects nAChR subunit expressions in the developing brainstem... - Proteomic MALDI-TOF/TOF-IMS examination of peptide expression in the formalin fixed brainstem and changes in sudden infant death syndrome infantsNicholas J Hunt
Department of Medicine, Central Clinical School, University of Sydney, NSW, Australia BOSCH Institute of Biomedical Research, University of Sydney, NSW, Australia
J Proteomics 138:48-60. 2016..This suggests that SIDS infants have abnormal neurological development in the raphe nuclei, hypoglossal and pyramids of the brainstem, which may contribute to the pathogenesis of SIDS... - Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent hypercapnic hypoxia (IHH) and nicotineMeichien Say
Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
Brain Res 1152:17-26. 2007..The findings support our hypothesis that 5-HT receptor abnormalities may be caused by postnatal exposures to clinically-relevant stimuli such as cigarette smoke exposure and/or prone sleeping... - Brain-derived neurotrophic factor (BDNF) and TrkB in the piglet brainstem after post-natal nicotine and intermittent hypercapnic hypoxiaSamantha Tang
Department of Paediatrics and Child Health, The University of Sydney, and The Children s Hospital, Westmead Sydney, NSW 2006, Australia
Brain Res 1232:195-205. 2008.... - Intermittent hypercapnic hypoxia induced protein changes in the piglet hippocampus identified by MALDI-TOF-MSSamantha Tang
Discipline of Pediatrics and Child Health, University of Sydney, Sydney, NSW 2006, Australia
Neurochem Res 34:2215-25. 2009.... - Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstemSamantha Tang
Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia Bosch Institute, The University of Sydney, NSW 2006, Australia
Respir Physiol Neurobiol 180:25-33. 2012..Abnormal expression of BDNF and TrkB suggests that neuroprotective functions of the BDNF/TrkB system may be reduced in respiratory-related nuclei of SIDS infants... - Increased neuronal cell death after intermittent hypercapnic hypoxia in the developing piglet brainstemRita Machaalani
Department of Medicine, Room 206, Blackburn Building, D06, University of Sydney, Sydney, NSW 2006, Australia
Brain Res 985:127-34. 2003..This could have important implications for clinical conditions including obstructive apnea and prone sleeping as a risk for SIDS... - Effects of cigarette smoke exposure on nicotinic acetylcholine receptor subunits α7 and β2 in the sudden infant death syndrome (SIDS) brainstemRita Machaalani
Department of Medicine, The University of Sydney, NSW 2006, Australia
Toxicol Appl Pharmacol 257:396-404. 2011.... - Neuronal cell death in the Sudden Infant Death Syndrome brainstem and associations with risk factorsRita Machaalani
Department of Medicine, Room 206, Blackburn Building, D06, The University of Sydney, NSW 2006, Australia
Brain 131:218-28. 2008.... - NMDA receptor 1 expression in the brainstem of human infants and its relevance to the sudden infant death syndrome (SIDS)Rita Machaalani
Department of Medicine, The University of Sydney, Westmead, Sydney, Australia
J Neuropathol Exp Neurol 62:1076-85. 2003..Further studies will be required to delineate these abnormalities and to investigate potential underlying mechanisms and sequelae... - Cumulative effects of repetitive intermittent hypercapnic hypoxia on orexin in the developing piglet hypothalamusMan K Du
Department of Pathology, University of Sydney, NSW 2006, Australia The BOSCH Institute, University of Sydney, NSW 2006, Australia
Int J Dev Neurosci 48:1-8. 2016..001). These findings indicate that a chronic IHH exposure induces greater changes in orexin neuropeptide expression than an acute 1-day exposure in the hypothalamus. This may be causally related to the dysregulation of sleep... - Brain-derived neurotrophic factor mRNA and protein in the piglet brainstem and effects of Intermittent Hypercapnic HypoxiaTanya Shyami Peiris
Department of Pathology, Room 206, Blackburn Building, DO6, University of Sydney, Sydney, NSW 2006, Australia
Brain Res 1029:11-23. 2004..Implications of the wide distribution of BDNF in the piglet caudal medulla and increased expression after IHH exposure are discussed, with particular reference to roles for BDNF-dependent neurons at this stage of development... - NMDA receptors in the developing brain and effects of noxious insultsKaren A Waters
Department of Medicine, Room 206, Blackburn Building, D06, The University of Sydney, Sydney, NSW 2006, Australia
Neurosignals 13:162-74. 2004..By highlighting knowledge gaps in this field, we hope to encourage future research focusing on clinically relevant problems and outcomes in this area... - Prenatal cigarette smoke exposure effects on apoptotic and nicotinic acetylcholine receptor expression in the infant mouse brainstemArunnjah Vivekanandarajah
The Bosch Institute, University of Sydney, Australia Department of Medicine, Blackburn Building, DO6, University of Sydney, NSW 2006, Australia
Neurotoxicology 53:53-63. 2016..This is the first study to demonstrate that nAChR subunits are affected following pre- into post-natal SE and that they simultaneously coincided with changes in apoptotic expression. .. - Decreased orexin (hypocretin) immunoreactivity in the hypothalamus and pontine nuclei in sudden infant death syndromeNicholas J Hunt
Department of Medicine, Room 206, SIDS and Sleep Apnoea Laboratory, Sydney Medical School, University of Sydney, Blackburn Building, D06, Sydney, NSW, 2006, Australia
Acta Neuropathol 130:185-98. 2015..This finding of reduced orexin immunoreactivity in SIDS infants may be associated with sleep dysfunction and impaired arousal... - The dorsal motor nucleus of the vagus (DMNV) in sudden infant death syndrome (SIDS): pathways leading to apoptosisCharbel Bejjani
Sydney Medical Program, University of Sydney, NSW 2006, Australia Australia
Respir Physiol Neurobiol 185:203-10. 2013.... - Immunolocalization of pro- and mature-brain derived neurotrophic factor (BDNF) and receptor TrkB in the human brainstem and hippocampusSamantha Tang
Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
Brain Res 1354:1-14. 2010..We conclude that BDNF and TrkB play important roles in controlling respiration, movement, balance and feeding in the brainstem and that the TrkB receptor is the most age-sensitive component of this system, especially in the hippocampus... - Changes in orexinergic immunoreactivity of the piglet hypothalamus and pons after exposure to chronic postnatal nicotine and intermittent hypercapnic hypoxiaNicholas J Hunt
Department of Medicine, Central Clinical School, University of Sydney, Camperdown, NSW, Australia
Eur J Neurosci 43:1612-22. 2016..Thus, although both nicotine and IHH are risk factors for SIDS, it appears they have opposing effects on OxA and OxB expression, with the IHH exposure closely mimicking what we recently found in SIDS. .. - Effects of post-mortem intervals on regional brain protein profiles in rats using SELDI-TOF-MS analysisRita Machaalani
Department of Medicine, The University of Sydney, NSW 2006, Australia
Neurochem Int 57:655-61. 2010.... - Distribution and quantification of NMDA R1 mRNA and protein in the piglet brainstem and effects of intermittent hypercapnic hypoxia (IHH)Rita Machaalani
Department of Medicine, Room 206 Blackburn Building, DO6, University of Sydney, Sydney, NSW 2006, Australia
Brain Res 951:293-300. 2002..NR1 mRNA expression increased while the number of neurons expressing NR1 protein showed no change. This finding suggests that NMDA pathways are activated by exposure to IHH... - Role of NMDA receptors in development of respiratory controlKaren A Waters
Department of Medicine, Room 206, Blackburn Building, DO6, University of Sydney, NSW 2006, Australia
Respir Physiol Neurobiol 149:123-30. 2005..NMDA receptor expression has also been measured histologically, and more recently knockout animal models have been used to provide additional functional information... - Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 ExpressionNicholas J Hunt
SIDS and Sleep Apnoea Laboratory, Department of Medicine, Sydney Medical School, University of Sydney, Room 206, Blackburn Building, D06, Sydney, NSW, Australia
Mol Neurobiol . 2016..As pPERK may inhibit multiple neuronal groups in the pons in SIDS infants, it could also indicate that a common pathway promotes loss of protein expression and impaired functionality of multiple brainstem neuronal groups... - Nicotinic acetylcholine receptors (nAChR) are increased in the pre-eclamptic placentaRita Machaalani
Department of Medicine, School of Medical Sciences, The University of Sydney, New South Wales, Australia
Hypertens Pregnancy 34:227-40. 2015..This study aimed to determine the effects of pre-eclampsia on the mRNA and protein expression of 12 mammalian nAChR subunits... - Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamusNicholas J Hunt
Department of Medicine, Central Clinical School, University of Sydney, New South Wales, Australia SIDS and Sleep Apnea Laboratory, Bosch Institute of Biomedical Research, University of Sydney, New South Wales, Australia
Neurobiol Aging 36:292-300. 2015..001). These results demonstrate a decrease in Ox expression with normal human maturation and aging. This may contribute to changes in sleep regulation during development and with aging... - Comparative proteomics in the corpus callosal sub-regions of postmortem human brainMohammed A Kashem
University of Sydney, NSW, Australia
Neurochem Int 55:483-90. 2009..Protein expression maps of these regions can be used as a reference source for future studies to investigate the molecular basis of functional differences and degree of pathogenesis of various neurodegenerative diseases of the CC... - Postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstemArunnjah Vivekanandarajah
The Bosch Institute, NSW 2006, Australia Department of Medicine, Blackburn Building, DO6, University of Sydney, NSW 2006, Australia
Int J Dev Neurosci 47:183-91. 2015..This is the first demonstration that non-classical nAChR subunits are affected by postnatal nicotine in the developing brain, and the implications are discussed. .. - Neurochemical abnormalities in the brainstem of the Sudden Infant Death Syndrome (SIDS)Rita Machaalani
Department of Medicine, Room 206, Blackburn Building, D06, The University of Sydney, NSW 2006, Australia The BOSCH Institute, Room 206, Blackburn Building, D06, The University of Sydney, NSW 2006, Australia Electronic address
Paediatr Respir Rev 15:293-300. 2014..We discuss the implications of these findings and directions that this may lead in future research. .. - Vascular endothelial growth factor receptor 1 (Flt1) and apoptosis in the preeclamptic placenta and effects of in vivo anti-hypertensive exposureRita Machaalani
Department of Medicine, University of Sydney, NSW, Australia
Hypertens Pregnancy 27:361-73. 2008..To test the hypothesis that vascular endothelial growth factor receptor 1 (Flt1) is negatively correlated with apoptosis in preeclampsia placentae, and to examine the effects of antihypertensive medication on apoptosis...