- Waterhouse N, Sedelies K, Trapani J. Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis. Immunol Cell Biol. 2006;84:72-8 pubmed..In this study, we discuss our recent findings on granzyme B-induced cell death and discuss the potential relevance of this pathway to CL-induced death of viral-infected and transformed cells. ..
- Waterhouse N, Sutton V, Sedelies K, Ciccone A, Jenkins M, Turner S, et al. Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis. J Cell Biol. 2006;173:133-44 pubmed..Therefore, CTLs from granzyme AB(-/-) mice induce target cell death by a unique mechanism that is distinct from both perforin lysis and apoptosis. ..
- Waterhouse N, Sedelies K, Browne K, Wowk M, Newbold A, Sutton V, et al. A central role for Bid in granzyme B-induced apoptosis. J Biol Chem. 2005;280:4476-82 pubmed..Unlike wild type cells, Bid-deficient cells survived and were then able to proliferate normally, demonstrating the critical role for Bid in mediating granzyme B-induced apoptosis. ..
- Waterhouse N, Trapani J. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007;28:373-5 pubmed....