N J Waterhouse

Summary

Affiliation: Peter MacCallum Cancer Centre
Country: Australia

Publications

  1. ncbi Mitochondria, apoptosis and autoimmunity
    Michael J Pinkoski
    Medical Research Council, Toxicology Unit, Leicester, UK
    Curr Dir Autoimmun 9:55-73. 2006
  2. pmc Granzyme B; the chalk-mark of a cytotoxic lymphocyte
    Nigel J Waterhouse
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, 8006, Australia
    J Transl Med 2:36. 2004
  3. ncbi Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis
    Nigel J Waterhouse
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:72-8. 2006
  4. ncbi Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
    N J Waterhouse
    Cancer Cell Death, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 13:607-18. 2006
  5. ncbi A central role for Bid in granzyme B-induced apoptosis
    Nigel J Waterhouse
    Cancer Cell Death, Gene Regulation, and Immune Signaling Laboratories, Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006
    J Biol Chem 280:4476-82. 2005
  6. pmc Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
    Nigel J Waterhouse
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia
    J Cell Biol 173:133-44. 2006
  7. ncbi Cytotoxic lymphocytes; instigators of dramatic target cell death
    Nigel J Waterhouse
    Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, VIC 8006, Australia
    Biochem Pharmacol 68:1033-40. 2004
  8. ncbi H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells
    Nigel J Waterhouse
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, Melbourne, Victoria 3002, Australia
    Trends Immunol 28:373-5. 2007
  9. ncbi A 'polarized' look at alpha-tubulin cleavage by granzyme B
    N J Waterhouse
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 13:1839-41. 2006
  10. doi Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity
    K A Sedelies
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 15:708-17. 2008

Collaborators

  • P I Bird
  • Joseph A Trapani
  • R W Johnstone
  • D R Green
  • Sarah Russell
  • M J Smyth
  • J Silke
  • Stephen J Turner
  • Patrick O Humbert
  • Michael Bots
  • Ilia Voskoboinik
  • HELEN BEERE
  • K A Sedelies
  • Jane Oliaro
  • Vivien R Sutton
  • O Susanto
  • V R Sutton
  • C H Bird
  • Kylie A Browne
  • M E Christensen
  • Mandy J Ludford-Menting
  • Anupama Pasam
  • Anna Colell
  • Michael J Pinkoski
  • Janice M Kelly
  • Melissa J Peart
  • Robyn Warrener
  • M D Prakash
  • I Harper
  • M S J Mangan
  • M Hagn
  • S Ellis
  • S Asquith
  • D Brasacchio
  • S E Stewart
  • R M Kluck
  • K Sedelies
  • G Dewson
  • Faruk Sacirbegovic
  • John T Chang
  • Kim Pham
  • Ze ev Bomzon
  • Min Gu
  • Edwin D Hawkins
  • Steven L Reiner
  • Vanessa van Ham
  • Chris J P Clarke
  • Sally V Watt
  • Leonie A Cluse
  • David J Izon
  • Natalie Thompson
  • F L Scott
  • A Ciccone
  • J Oliaro
  • Kylie Browne
  • Katherine Baran
  • C J P Clarke
  • Sandra Milasta
  • Aulikki Koskinen
  • Stephen Tait
  • Pascal Barbry
  • Donald D Newmeyer
  • Lisa Bouchier-Hayes
  • Arno Mullbacher
  • Patrick Fitzgerald
  • Karin Sedelies
  • Ulrich Maurer
  • Cindy Wei Li
  • Desiree Anthony
  • Ana Guio-Carrion
  • Annette Ciccone
  • Jean Ehrland Ricci
  • Bernard Mari
  • Erika Cretney
  • Sarah Ellis
  • Kellie M Tainton
  • Anthony E Dear
  • Andrew Burgess
  • Lorraine A O'Reilly
  • Nichole Giles
  • David Fairlie
  • Brian Gabrielli
  • Astrid A Ruefli
  • Heather Beamish
  • Karin A Sedelies

Detail Information

Publications25

  1. ncbi Mitochondria, apoptosis and autoimmunity
    Michael J Pinkoski
    Medical Research Council, Toxicology Unit, Leicester, UK
    Curr Dir Autoimmun 9:55-73. 2006
    ....
  2. pmc Granzyme B; the chalk-mark of a cytotoxic lymphocyte
    Nigel J Waterhouse
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, 8006, Australia
    J Transl Med 2:36. 2004
    ..In this way, the released granzyme B can be used to mark the spot where a target cell was murdered. We discuss the benefits and potential limitations of using this assay to measure CL mediated killing of target cells...
  3. ncbi Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis
    Nigel J Waterhouse
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:72-8. 2006
    ..In this study, we discuss our recent findings on granzyme B-induced cell death and discuss the potential relevance of this pathway to CL-induced death of viral-infected and transformed cells...
  4. ncbi Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
    N J Waterhouse
    Cancer Cell Death, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 13:607-18. 2006
    ..This functional dissociation of cytochrome c and SMAC release from loss of DeltaPsim demonstrates the essential contribution of Bid upstream of caspase activation during granzyme B-induced apoptosis...
  5. ncbi A central role for Bid in granzyme B-induced apoptosis
    Nigel J Waterhouse
    Cancer Cell Death, Gene Regulation, and Immune Signaling Laboratories, Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006
    J Biol Chem 280:4476-82. 2005
    ..Unlike wild type cells, Bid-deficient cells survived and were then able to proliferate normally, demonstrating the critical role for Bid in mediating granzyme B-induced apoptosis...
  6. pmc Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
    Nigel J Waterhouse
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia
    J Cell Biol 173:133-44. 2006
    ..Therefore, CTLs from granzyme AB(-/-) mice induce target cell death by a unique mechanism that is distinct from both perforin lysis and apoptosis...
  7. ncbi Cytotoxic lymphocytes; instigators of dramatic target cell death
    Nigel J Waterhouse
    Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, VIC 8006, Australia
    Biochem Pharmacol 68:1033-40. 2004
    ....
  8. ncbi H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells
    Nigel J Waterhouse
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, Melbourne, Victoria 3002, Australia
    Trends Immunol 28:373-5. 2007
    ....
  9. ncbi A 'polarized' look at alpha-tubulin cleavage by granzyme B
    N J Waterhouse
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 13:1839-41. 2006
  10. doi Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity
    K A Sedelies
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 15:708-17. 2008
    ....
  11. pmc Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis
    O Susanto
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cell Death Differ 20:1183-93. 2013
    ..This work defines an authentic role for mouse Gzm A in granule-induced cell death by cytotoxic lymphocytes. ..
  12. pmc Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737
    V R Sutton
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia
    Cell Death Dis 3:e344. 2012
    ..This defines a therapeutic window in which ABT-737 and CL synergise to cause maximum death of cancer cells that are resistant to either treatment alone, which will be essential in defining optimum treatment regimens...
  13. ncbi Granzyme M mediates a novel form of perforin-dependent cell death
    Janice M Kelly
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, 8006 Victoria, Australia
    J Biol Chem 279:22236-42. 2004
    ..These data raise the likelihood that granzyme M represents a third major and specialized perforin-dependent cell death pathway that plays a significant role in death mediated by NK cells...
  14. pmc Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis
    Vivien R Sutton
    Cancer Immunology Program, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    J Cell Biol 176:425-33. 2007
    ..Cathepsin C deficiency also results in considerably milder immune deficiency than perforin or granzyme A/B deficiency...
  15. ncbi Calreticulin: raising awareness of apoptosis
    Nigel J Waterhouse
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Apoptosis 12:631-4. 2007
  16. pmc The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress
    C H Bird
    Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Vic, Australia
    Cell Death Differ 21:876-87. 2014
    ..The GrB-Sb9 nexus may therefore represent an additional mechanism of limiting lymphocyte lifespan and populations...
  17. ncbi Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
    Melissa J Peart
    Cancer Immunology Program, The Peter MacCallum Cancer Institute, East Melbourne 3002, Victoria, Australia
    Cancer Res 63:4460-71. 2003
    ....
  18. ncbi Assaying cytochrome C translocation during apoptosis
    Nigel J Waterhouse
    Cancer Immunology, Research Division, Peter MacCallum Cancer Center, Melbourne, Australia
    Methods Mol Biol 284:307-13. 2004
    ..In this chapter, we highlight separation of cytosolic and mitochondrial fractions of cultured cells using digitonin as the method for measuring cytochrome c release that, in our hands has been the simplest and most reproducible...
  19. ncbi The cellular energy crisis: mitochondria and cell death
    Nigel J Waterhouse
    Cancer Immunology Research, Peter MacCallum Cancer Institute, Melbourne, Australia
    Med Sci Sports Exerc 35:105-10. 2003
    ..The events surrounding the breach of the mitochondrial outer membrane during apoptosis have therefore received much interest over the past few years...
  20. pmc Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms
    Jane Oliaro
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia
    J Immunol 185:367-75. 2010
    ..These findings suggest that T cells have selectively adapted a number of evolutionarily conserved mechanisms to generate diversity through asymmetric cell division...
  21. doi Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules
    Vivien R Sutton
    Cancer Cell Death Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006, Australia
    Methods 44:241-9. 2008
    ..As cell death mediated through TNF-superfamily members and their respective receptors is covered elsewhere, this manuscript will deal specifically with cytotoxic granule-mediated cell death...
  22. pmc Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation
    Jane Oliaro
    Immune Signalling Laboratory, Peter MacCallum Cancer Centre, Faculty of Medicine, University of Melbourne, St Andrew s Place, East Melbourne, VIC 3010, Australia
    Proc Natl Acad Sci U S A 103:18685-90. 2006
    ..These data indicate that external signals can alter lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function...
  23. ncbi GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation
    Anna Colell
    Department of Cell Death and Proliferation, Institut d Investigacions Biomediques de Barcelona IIBB CSIC, IDIBAPS, 08036 Barcelona, Spain
    Cell 129:983-97. 2007
    ..Therefore, GAPDH mediates an elevation in glycolysis and enhanced autophagy that cooperate to protect cells from CICD...
  24. ncbi Tumor cell-selective cytotoxicity by targeting cell cycle checkpoints
    Robyn Warrener
    Cancer Biology Program, Centre for Immunology and Cancer Research, University of Queensland, Brisbane, Queensland 4102, Australia
    FASEB J 17:1550-2. 2003
    ..This study of histone deacetylase inhibitors demonstrates that drugs targeting cell cycle checkpoints can provide the selectivity and cytotoxicity desired in effective chemotherapeutic agents...
  25. ncbi And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis
    Nigel J Waterhouse
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA
    Biochimie 84:113-21. 2002
    ..It is still unclear how these proteins are released from the mitochondria. Recent advances in our knowledge of mitochondrial outer-membrane permeabilization and the consequences of this event on mitochondria will be discussed...