Research Topics
| R HollidaySummaryCountry: Australia Publications
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Publications
A global view of the causes of ageing: an interview with Robin Holliday
Robin Holliday
Biogerontology 3:317-24. 2002Dual inheritance
R Holliday
Curr Top Microbiol Immunol 301:243-56. 2006..There have also been innumerable studies on the abnormal de novo methylation and silencing of tumour suppressor genes in cancer cells...Interconnections between genetics, ageing, pathology and medicine, as revealed in an interview with George Martin. Interview by Robin Holliday
George Martin
Biogerontology 7:297-303. 2006Evolution of optimal accuracy and stability in biological systems
Robin Holliday
The Australian Academy of Science, Canberra, Australia, 12 Roma Court, West Pennant Hills, N S W 2125, Australia
Chem Biodivers 4:1972-8. 2007Epigenetics: a historical overview
Robin Holliday
Epigenetics 1:76-80. 2006..The human epigenome project will unravel the pattern of DNA methylation in different tissues, and will this determine whether the regulation of gene expression is at the level of DNA or chromatin, or both...Telomeres and telomerase: the commitment theory of cellular ageing revisited
Robin Holliday
Australian Academy of Science, Canberra, Australia
Sci Prog 95:199-205. 2012..The stochastic feature of the theory is the probability of the loss of the last uncommitted cells or the youngest committed cells. These cells have the longest lifespan and will give rise to the final population...DNA methylation and epigenotypes
R Holliday
Biochemistry (Mosc) 70:500-4. 2005..Much is already known about the de novo methylation of tumor suppressor genes in cancer cells, but the significance of epigenetic defects during ageing and in some familial diseases remains to be determined...Ageing and the extinction of large animals
Robin Holliday
Biogerontology 6:151-6. 2005..Fluctuating environments are more likely to promote the evolution of small short-lived species with high fecundity...Streptomycin, errors in mitochondria and ageing
Robin Holliday
Biogerontology 6:431-2. 2005Food, fertility and longevity
Robin Holliday
Biogerontology 7:139-41. 2006..Hibernation is a natural form of calorie restriction, and in some cases may lengthen lifespan...Aging is no longer an unsolved problem in biology
Robin Holliday
Australian Academy of Science, Canberra
Ann N Y Acad Sci 1067:1-9. 2006..We can therefore conclude that this evolved design is intrinsically related to the fact of aging. This in turn means that aging cannot be reversed, although it may be modulated, as, for example, by calorie restriction...Meiosis and sex: potent weapons in the competition between early eukaryotes and prokaryotes
Robin Holliday
Bioessays 28:1123-5. 2006..Meiosis and sex could have arisen in an asexually reproducing species and formed a clonal population...Physics and the origins of molecular biology
Robin Holliday
J Genet 85:93-7. 2006..The strength and success of molecular biology came from the many interactions between geneticists, physicists, chemists and biochemists. It was also characterized by a powerful combination of theoretical and experimental approaches...The extreme arrogance of anti-aging medicine
Robin Holliday
Australian Academy of Science, Canberra, Australia
Biogerontology 10:223-8. 2009..The anti-aging movement proposes in a few decades to reverse what has been the result of millions of years of evolution...The recombination, repair and modification of DNA
Robin Holliday
DNA Repair (Amst) 10:993-9. 2011..The hypothesis that DNA methylation has a role in gene expression in higher organism is now supported by abundant evidence. Direct evidence that gene silencing in mammalian cells is causally related to DNA methylation has been obtained...The multiple and irreversible causes of aging
Robin Holliday
12 Roma Court, West Pennant Hills, Sydney, NSW 2125, Australia
J Gerontol A Biol Sci Med Sci 59:B568-72. 2004..The failure of maintenance is irreversible, although longevity may be modulated under certain circumstances, such as dietary restriction accompanied by a loss of fertility...The close relationship between biological aging and age-associated pathologies in humans
Robin Holliday
12 Roma Court, West Pennant Hills, Sydney, NSW 2125, Australia
J Gerontol A Biol Sci Med Sci 59:B543-6. 2004..The eventual failure to maintain the integrity of tissues and organs is the end result of the multiple causes of aging...Early studies on recombination and DNA repair in Ustilago maydis
Robin Holliday
DNA Repair (Amst) 3:671-82. 2004..Much more recently, the revolution in molecular genetics has been in exploited in several laboratories working with Ustilago maydis, and these have produced some completely new insights into recombination and repair...Causes of aging
R Holliday
CSIRO Molecular Science, Sydney Laboratory, North Ryde, NSW, Australia
Ann N Y Acad Sci 854:61-71. 1998..The major aim of such research is to devise procedures to delay or prevent the onset of these diseases...A role for carnosine in cellular maintenance
R Holliday
CSIRO Division of Molecular Science, North Ryde, Sydney, NSW 1670, Australia
Biochemistry (Mosc) 65:843-8. 2000..In the absence of pyruvate, carnosine is cytotoxic to neoplastic and transformed human and rodent cells. None of these effects are seen with its optical isomer, D-carnosine...Human ageing and the origins of religion
R Holliday
Biogerontology 2:73-7. 2001..Religion then became the basis for the moral code, and it provided an assurance of continual survival after death...Twenty years of ageing research at the Mill Hill laboratories
Robin Holliday
The Royal Society, 6 Carlton House Terrace, London SW1, UK
Exp Gerontol 37:851-7. 2002....Epigenetics comes of age in the twentyfirst century
Robin Holliday
J Genet 81:1-4. 2002Understanding ageing
R Holliday
CSIRO Division of Biomolecular Engineering, Sydney Laboratory, North Ryde, NSW, Australia
Philos Trans R Soc Lond B Biol Sci 352:1793-7. 1997..The major aim of such research is to devise procedures to delay or prevent the onset of these diseases...Gene silencing and endogenous DNA methylation in mammalian cells
R Holliday
Division of Molecular Science, Sydney Laboratory P O Box 184, North Ryde, NSW, Sydney, Australia
Mutat Res 400:361-8. 1998..It seems that 5-methyldCMP deaminase can be down-regulated in transformed cells, and this can promote de novo methylation by incorporation of 5-methyldCTP derived from 5-methyldCMP...Evidence for gene silencing by endogenous DNA methylation
R Holliday
Commonwealth Scientific and Industrial Research Organization, Molecular Science, Sydney Laboratory, P O Box 184, North Ryde NSW 2113, Australia
Proc Natl Acad Sci U S A 95:8727-32. 1998..It also has low 5-methyl-dCMP deaminase activity. Another HAM+ strain has high deaminase activity and a very low frequency of gene silencing. The starting strain, CHO K1, has a phenotype intermediate between HAM- and HAM+...Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine
R Holliday
CSIRO Division of Biomolecular Engineering, Sydney Laboratory, NSW, Australia
Br J Cancer 73:966-71. 1996..It is well known that tumour cells are more dependent on glycolysis than normal cells. A reduction of glycolysis intermediates by carnosine may deplete their energy supply, but this effect is totally reversed by pyruvate...John Robert Stanley Fincham: 11 August 1926 - 9 February 2005
Robin Holliday
Biogr Mem Fellows R Soc 52:83-95. 2006..He was also a practitioner and lover of sports and in his early career was politically active. His successes in life made him an extraordinarily talented man who achieved much as a leader in genetics in the UK and internationally...The homologous recombination system of Ustilago maydis
William K Holloman
Cornell University Weill Medical College, Department of Microbiology and Immunology, NY 10021, USA
Fungal Genet Biol 45:S31-9. 2008..These include the use of a BRCA2 homolog and its modifier Dss1 rather than Rad52 as a mediator of Rad51, the presence of only a single Rad51 paralog, and the absence of Dmc1 and auxiliary meiotic proteins...Towards understanding the extreme radiation resistance of Ustilago maydis
William K Holloman
Cornell University Weill Medical College, Department of Microbiology and Immunology, New York, NY 10021, USA
Trends Microbiol 15:525-9. 2007..maydis. Evolution of a system enabling the survival of U. maydis under such conditions could be a secondary consequence of adaptation to an environment of continual genotoxic stress encountered in its habitat...Francis Crick (1916-2004)
Robin Holliday
12 Roma Court, West Pennant Hills, Sydney, NSW 2125, Australia
Cell 119:1-2. 2004Evolution of human longevity, population pressure and the origins of warfare
Robin Holliday
pond com
Biogerontology 6:363-8. 2005..This inevitably occurred at the same time as man gradually gained more control over his environment, and achieved far more reproductive success than is seen in hunter-gatherers living in a harsh, stressful environment...The early years of molecular biology: personal recollections
Robin Holliday
Notes Rec R Soc Lond 57:195-208. 2003..Nevertheless, proteins can chemically modify DNA, and this is now known to have strong effects on gene expression...Creationism and the wheel
Robin Holliday
Bioessays 25:620-1. 2003DNA methylation and epigenetic inheritance
Robin Holliday
Sydney Laboratory, CSIRO Molecular Science, P O Box 184, North Ryde, New South Wales 2113, Australia
Methods 27:179-83. 2002..Nevertheless, much more information is required about the effects of DNA-damaging agents in changing DNA methylation and gene activity and also about the role of epimutations in tumor progression...