Arno Mullbacher

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. pmc Perforin is essential for control of ectromelia virus but not related poxviruses in mice
    A Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Virol 73:1665-7. 1999
  2. ncbi Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection
    A Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra City, ACT
    Eur J Immunol 29:1228-34. 1999
  3. ncbi Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections
    A Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
    J Immunol 162:7315-21. 1999
  4. pmc Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
    A Mullbacher
    Division of Immunology, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 96:13950-5. 1999
  5. ncbi Can we really learn from model pathogens?
    Arno Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Trends Immunol 25:524-8. 2004
  6. ncbi Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis
    Arno Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 169:145-50. 2002
  7. ncbi T-cell-mediated control of poxvirus infection in mice
    A Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra, ACT 2601, Australia
    Prog Mol Subcell Biol 36:39-55. 2004
  8. ncbi Cell-mediated cytotoxicity in recovery from poxvirus infections
    Arno Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Rev Med Virol 13:223-32. 2003
  9. pmc Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses
    Yoichi Furuya
    Viral Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Virol 84:4212-21. 2010
  10. ncbi NK cell-mediated immunopathology during an acute viral infection of the CNS
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Eur J Immunol 36:887-96. 2006

Collaborators

Detail Information

Publications33

  1. pmc Perforin is essential for control of ectromelia virus but not related poxviruses in mice
    A Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Virol 73:1665-7. 1999
    ..An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus...
  2. ncbi Spontaneous mutation at position 114 in H-2Kd affects cytotoxic T cell responses to influenza virus infection
    A Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra City, ACT
    Eur J Immunol 29:1228-34. 1999
    ..Kdw presented NPP147-155 encoded by the full-length NP gene, but Kdw-NPP147-155 complexes were at least 100-fold less abundant than after translation from a minigene...
  3. ncbi Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections
    A Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra
    J Immunol 162:7315-21. 1999
    ..We hypothesize that differences in TCR affinities and/or state of activation between alloreactive and MHC-restricted CTL as well as the quality (origin) of target cells are responsible for the observed phenomenon...
  4. pmc Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
    A Mullbacher
    Division of Immunology, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 96:13950-5. 1999
    ..These results establish that both gzmA and gzmB are indispensable effector molecules acting in concert with perforin in granule exocytosis-mediated host defense against natural viral pathogens...
  5. ncbi Can we really learn from model pathogens?
    Arno Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Trends Immunol 25:524-8. 2004
    ..Thus, virus-host immune interactions have to be assessed individually and cannot be generalized...
  6. ncbi Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis
    Arno Mullbacher
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 169:145-50. 2002
    ..The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses...
  7. ncbi T-cell-mediated control of poxvirus infection in mice
    A Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, P O Box 334, Canberra, ACT 2601, Australia
    Prog Mol Subcell Biol 36:39-55. 2004
  8. ncbi Cell-mediated cytotoxicity in recovery from poxvirus infections
    Arno Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Rev Med Virol 13:223-32. 2003
    ....
  9. pmc Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses
    Yoichi Furuya
    Viral Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    J Virol 84:4212-21. 2010
    ..Therefore, cross-protective immunity induced by vaccination with gamma-irradiated influenza A virus is mediated mainly by Tc-cell responses...
  10. ncbi NK cell-mediated immunopathology during an acute viral infection of the CNS
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Eur J Immunol 36:887-96. 2006
    ..This is the first study illustrating an NK cell-mediated immunopathological outcome to an acute viral infection...
  11. pmc CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis
    Yang Wang
    Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University, Canberra ACT 2601, Australia
    J Virol 77:13323-34. 2003
    ..Using high doses of virus in CD8-deficient mice leads to increased survival. These results provide evidence that CD8(+) T cells are involved in both recovery and immunopathology in WNV infection...
  12. doi Effect of inactivation method on the cross-protective immunity induced by whole 'killed' influenza A viruses and commercial vaccine preparations
    Yoichi Furuya
    Viral Immunology and Molecular Virology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Gen Virol 91:1450-60. 2010
    ..Finally, freeze-drying of gamma-A/PC did not affect the ability to induce cross-protective immunity...
  13. doi Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B
    Matthias Regner
    John Curtin School of Medical Research, Canberra, Australia
    J Immunol 183:37-40. 2009
    ..Specific target cell elimination occurred with similar kinetics in both spleen and lymph nodes. Thus, neither gzmA nor gzmB are required for rapid and efficient in vivo cytotoxicity by Tc cells...
  14. ncbi CD8(+) T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon
    Yang Wang
    Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University ANU, PO Box 334, Canberra, ACT 2601, Australia
    J Gen Virol 87:3599-609. 2006
    ....
  15. pmc The ectromelia virus SPI-2 protein causes lethal mousepox by preventing NK cell responses
    Carolina R Melo-Silva
    Department of Emerging Pathogens and Vaccines, John Curtin School of Medical Research, Australian National University, Canberra ACT, Australia
    J Virol 85:11170-82. 2011
    ..Consequently, SPI-2 renders mousepox lethal in susceptible strains by preventing protective NK cell defenses...
  16. pmc Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice
    Rosa M Licon Luna
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia
    J Virol 76:3202-11. 2002
    ..Mice deficient in both cytotoxic effector functions were resistant to a low-dose peripheral infection with the neurotropic virus...
  17. doi Restricted Semliki Forest virus replication in perforin and Fas-ligand double-deficient mice
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Gen Virol 89:1942-4. 2008
    ..Although the mechanism responsible for this observation is yet to be established, the lower virus titres found in these mice indicate that the role of cytolytic effector molecules in antiviral immunity needs to be re-evaluated...
  18. pmc Gamma-irradiated influenza virus uniquely induces IFN-I mediated lymphocyte activation independent of the TLR7/MyD88 pathway
    Yoichi Furuya
    Department of Emerging Pathogens and Vaccines, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 6:e25765. 2011
    ..This partial lymphocytes activation is mediated by type-I interferons (IFN-I). Importantly, we have shown that γ-irradiated SFV does not induce IFN-I and the associated lymphocyte activation...
  19. ncbi Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus
    Mario Lobigs
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    J Gen Virol 84:567-72. 2003
    ..In contrast, mice deficient in IFN-gamma or nitric oxide production display an only marginally increased susceptibility to infection with the neurotropic virus...
  20. pmc MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies
    Mohammed Alsharifi
    Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 8:e68458. 2013
    ..Detailed genetic analysis will be carried out to characterise the underlining genetic defects responsible for the observed phenomenon. ..
  21. ncbi Immunobiology of mosquito-borne encephalitic flaviviruses
    Arno Mullbacher
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra City, A C T 2601, Australia
    Adv Virus Res 60:87-120. 2003
  22. ncbi Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice
    Yang Wang
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, PO Box 334, Canberra, ACT 2601, Australia
    Immunol Cell Biol 82:170-3. 2004
    ..Virus-host immune interactions have to be assessed individually and cannot be generalized...
  23. pmc In vivo elimination of MHC-I-deficient lymphocytes by activated natural killer cells is independent of granzymes A and B
    Matthias Regner
    Department for Emerging Pathogens and Vaccines, John Curtin School of Medical Research, Canberra, Australia
    PLoS ONE 6:e23252. 2011
    ..Thus, similar to T cell cytotoxicity, the contribution of gzmA and B to in vivo target cell elimination remains unresolved...
  24. ncbi Type I interferons trigger systemic, partial lymphocyte activation in response to viral infection
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 175:4635-40. 2005
    ..We conclude that virus-induced IFN-I release systemically affects most of the hosts T and B cells by triggering them rapidly and independently of Ag-reactivity into a semiactivated state...
  25. ncbi The multidrug resistance gene mdr1a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity
    Dongmei Xu
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601
    Immunol Cell Biol 82:462-70. 2004
    ..Only dendritic cells from mdr1a-/- mice showed impaired migration to the draining lymph nodes compared to wt mice. Our data show that P-gp plays an important role in EV infection by as yet undefined mechanisms...
  26. pmc Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    PLoS ONE 4:e5336. 2009
    ..We have previously reported that gamma-ray inactivated flu virus can induce cross-reactive Tc cell responses...
  27. ncbi Evidence that a mechanism for efficient flavivirus budding upregulates MHC class I
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
    Immunol Cell Biol 82:184-8. 2004
    ....
  28. doi Interferon type I responses in primary and secondary infections
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 86:239-45. 2008
    ..The latter correlates with well-established clinical observations of heightened susceptibility of patients to secondary microbial infections after viral episodes...
  29. doi Antigen-specific activation thresholds of CD8+ T cells are independent of IFN-I-mediated partial lymphocyte activation
    Danushka K Wijesundara
    Viral Immunology, Emerging Pathogens and Vaccines Program, John Curtin School of Medical Research, Acton, ACT 0200, Canberra, Australia
    Int Immunol 22:757-67. 2010
    ....
  30. pmc Increased survival after gemfibrozil treatment of severe mouse influenza
    Alison Budd
    School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT, Australia
    Antimicrob Agents Chemother 51:2965-8. 2007
    ....
  31. ncbi MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen
    Mario Lobigs
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Immunol Cell Biol 81:217-23. 2003
    ....
  32. ncbi Exhaustion of type I interferon response following an acute viral infection
    Mohammed Alsharifi
    Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Immunol 177:3235-41. 2006
    ..Thus, transient immunosuppression through exhaustion of IFN-I production during an acute viral infection creates a time period of enhanced susceptibility to secondary infection...
  33. ncbi Granzymes in cytolytic lymphocytes--to kill a killer?
    Matthias Regner
    Molecular Immunology and Immunopathology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Immunol Cell Biol 82:161-9. 2004
    ..We discuss the predictions of the model in the light of available data...