Arno Mullbacher

Summary

Affiliation: Australian National University
Country: Australia

Publications

  1. Mullbacher A, Hla R, Museteanu C, Simon M. Perforin is essential for control of ectromelia virus but not related poxviruses in mice. J Virol. 1999;73:1665-7 pubmed
    ..An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus...
  2. Mullbacher A, Waring P, Tha Hla R, Tran T, Chin S, Stehle T, et al. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci U S A. 1999;96:13950-5 pubmed
    ..These results establish that both gzmA and gzmB are indispensable effector molecules acting in concert with perforin in granule exocytosis-mediated host defense against natural viral pathogens...
  3. Mullbacher A, Lobigs M, Hla R, Tran T, Stehle T, Simon M. Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis. J Immunol. 2002;169:145-50 pubmed
    ..The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses...
  4. Mullbacher A. Cell-mediated cytotoxicity in recovery from poxvirus infections. Rev Med Virol. 2003;13:223-32 pubmed
    ....

Locale

Detail Information

Publications4

  1. Mullbacher A, Hla R, Museteanu C, Simon M. Perforin is essential for control of ectromelia virus but not related poxviruses in mice. J Virol. 1999;73:1665-7 pubmed
    ..An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus...
  2. Mullbacher A, Waring P, Tha Hla R, Tran T, Chin S, Stehle T, et al. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci U S A. 1999;96:13950-5 pubmed
    ..These results establish that both gzmA and gzmB are indispensable effector molecules acting in concert with perforin in granule exocytosis-mediated host defense against natural viral pathogens...
  3. Mullbacher A, Lobigs M, Hla R, Tran T, Stehle T, Simon M. Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis. J Immunol. 2002;169:145-50 pubmed
    ..The results are discussed as to the possible relevance of the phenomenon in efficiency and regulation of the Tc cell response to infections by viruses...
  4. Mullbacher A. Cell-mediated cytotoxicity in recovery from poxvirus infections. Rev Med Virol. 2003;13:223-32 pubmed
    ....