Laila AL-Ayadhi

Summary

Affiliation: Autism Research & Treatment Center
Location: Riyadh, Saudi Arabia
Summary:
Biomarkers research in ASD
studding the effectiveness of some proposed intervention in ASD

Publications

  1. doi request reprint The possible link between elevated serum levels of epithelial cell-derived neutrophil-activating peptide-78 (ENA-78/CXCL5) and autoimmunity in autistic children.
    Gehan Ahmed Mostafa
    Behav Brain Funct 11:11. 2015
  2. doi request reprint Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism
    Maha Al-Askar
    Department of Biochemistry, Science College, King Saud University, Riyadh, Saudi Arabia
    BMC Complement Altern Med 17:259. 2017
  3. pmc Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Lipids Health Dis 13:140. 2014
  4. pmc Association of social and cognitive impairment and biomarkers in autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    J Neuroinflammation 11:4. 2014
  5. pmc A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Behav Brain Funct 10:14. 2014
  6. pmc Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism
    Mashael Al-Ghamdi
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Neurosci 15:34. 2014
  7. pmc Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups
    Hanan A Alfawaz
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Complement Altern Med 14:416. 2014
  8. pmc Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 11:69. 2014
  9. doi request reprint Camel Milk as a Potential Therapy as an Antioxidant in Autism Spectrum Disorder (ASD).
    Laila Y Al Ayadhi
    Department of Physiology, Faculty of Medicine, King Saud University, P O Box 2925, Riyadh 11461, Saudi Arabia
    Evid Based Complement Alternat Med 2013:602834. 2013
  10. pmc Lipid mediators in plasma of autism spectrum disorders
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    Lipids Health Dis 11:160. 2012

Collaborators

  • Afaf El-Ansary
  • Laila Y Al-Ayadhi
  • Afaf K El-Ansary
  • Laila AL-Ayadhi
  • Laila Yousef Al-Ayadhi
  • Gehan Ahmed Mostafa
  • Gehan A Mostafa
  • Altaf Alabdali
  • Abir G Ben Bacha
  • Maha Al-Askar
  • Ramesa Shafi Bhat
  • Hanan A Alfawaz
  • Mashael Al-Ghamdi
  • Laila Y Al Ayadhi
  • Ghada A Abu Shmais
  • Layla Y Al-Ayahdi
  • Yusra A Al-Yafee
  • Manar Selim
  • Laila Yousef Al Ayadhi
  • Amina R El-Gezeery
  • Ghada H Shaker
  • Nadra Elyass Elamin
  • Malak Kotb
  • Abeer M Al-Dbass
  • Samina H Haq

Detail Information

Publications27

  1. doi request reprint The possible link between elevated serum levels of epithelial cell-derived neutrophil-activating peptide-78 (ENA-78/CXCL5) and autoimmunity in autistic children.
    Gehan Ahmed Mostafa
    Behav Brain Funct 11:11. 2015
    ..The possible therapeutic role of ENA-78 antagonist in autistic children should be also studied...
  2. doi request reprint Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism
    Maha Al-Askar
    Department of Biochemistry, Science College, King Saud University, Riyadh, Saudi Arabia
    BMC Complement Altern Med 17:259. 2017
    ..Mothers undergoing VPA treatment during early pregnancy reportedly show increased rates of autism among their offspring. The benefits of curcumin supplementation were investigated using an animal model of VPA-induced autism...
  3. pmc Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Lipids Health Dis 13:140. 2014
    ..Omega-3 PUFAs mediate some of these effects by antagonizing Omega-6 PUFA (arachidonic acid, AA)-induced proinflammatory prostaglandin E₂ (PGE₂) formation...
  4. pmc Association of social and cognitive impairment and biomarkers in autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    J Neuroinflammation 11:4. 2014
    ....
  5. pmc A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Behav Brain Funct 10:14. 2014
    ..e., mild, moderate and severe) will give greater insight into the pathogenesis of this disease and will enable effective early diagnostic strategies and treatments for this disorder...
  6. pmc Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism
    Mashael Al-Ghamdi
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Neurosci 15:34. 2014
    ..Heat shock protein70 (Hsp70), Gamma amino-butyric acid (GABA), serotonin, dopamine, oxytocin and interferon γ-inducible protein 16 together with Comet DNA assay were measured in brain tissues of the six studied groups...
  7. pmc Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups
    Hanan A Alfawaz
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Complement Altern Med 14:416. 2014
    ..The present study investigated the protective and/or therapeutic effects of vitamin D against brain intoxication induced by propionic acid (PPA) in rats...
  8. pmc Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 11:69. 2014
    ..Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of antinucleosome-specific antibodies in a group of autistic children...
  9. doi request reprint Camel Milk as a Potential Therapy as an Antioxidant in Autism Spectrum Disorder (ASD).
    Laila Y Al Ayadhi
    Department of Physiology, Faculty of Medicine, King Saud University, P O Box 2925, Riyadh 11461, Saudi Arabia
    Evid Based Complement Alternat Med 2013:602834. 2013
    ....
  10. pmc Lipid mediators in plasma of autism spectrum disorders
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    Lipids Health Dis 11:160. 2012
    ..The genesis of this disorder is still not understood but inflammation in utero or early in childhood is an environmental risk factor...
  11. pmc Neuroinflammation in autism spectrum disorders
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O, Box 22452, 11495, Riyadh, Saudi Arabia
    J Neuroinflammation 9:265. 2012
    ..This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β2, Caspase 7 and interferon-γ (IFN-γ)in the pathophysiology of autism...
  12. pmc Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity
    Gehan A Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:201. 2012
    ..We are the first to investigate the relationship between serum levels of 25-hydroxy vitamin D and anti-myelin-associated glycoprotein (anti-MAG) auto-antibodies in autistic children...
  13. pmc Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism
    Ghada A Abu Shmais
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    J Neurodev Disord 4:4. 2012
    ..Although this has not been investigated to date, several recent studies proposed that nitrogen metabolism-related parameters may have a pathophysiological role in autism...
  14. pmc The neurotoxic effect of clindamycin - induced gut bacterial imbalance and orally administered propionic acid on DNA damage assessed by the comet assay: protective potency of carnosine and carnitine
    Afaf El-Ansary
    Department of Biochemistry, College of Science, King Saud University, P, O Box 22452, Riyadh 11495, Saudi Arabia
    Gut Pathog 5:9. 2013
    ..Additionally, the protective effect of carnosine and carnitine as natural dietary supplements is assessed...
  15. pmc Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Lipids Health Dis 10:62. 2011
    ..The aim of this study is to compare plasma fatty acid profiles of Saudi autistic patients with those of age-matching control subjects in an attempt to clarify the role of FA in the etiology of autism...
  16. pmc Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, PO Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Lipids Health Dis 10:63. 2011
    ....
  17. pmc The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism
    Gehan A Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:180. 2011
    ..We are the first to measure serum neurokinin A levels in autistic children. The relationship between serum levels of neurokinin A and anti-ribosomal P protein antibodies was also studied...
  18. pmc Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    J Neuroinflammation 8:142. 2011
    ..This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and proapoptotic biomarkers...
  19. pmc A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children
    Gehan Ahmed Mostafa
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:71. 2011
    ..We are the first to investigate the possible role of hyperserotonemia in the induction of autoimmunity, as indicated by serum anti-myelin-basic protein (anti-MBP) auto-antibodies, in autism...
  20. pmc Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity
    Gehan A Mostafa
    Autism Research and Treatment Center, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:39. 2011
    ..We are the first to measure the relationship between these antibodies and the degree of the severity of autism...
  21. pmc Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia
    Yusra A Al-Yafee
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    BMC Neurol 11:139. 2011
    ....
  22. pmc Elevated serum levels of interleukin-17A in children with autism
    Laila Yousef Al-Ayadhi
    Department of Physiology, Autism Research and Treatment Center, AL Amodi Autism Research Chair, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:158. 2012
    ..The aim of this study was to measure serum levels of IL-17A in relation to the degree of the severity of autism...
  23. pmc A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:54. 2012
    ..We are the first to investigate the relationship between serum levels of S100B protein, a marker of neuronal damage, and antiribosomal P protein antibodies in autistic children...
  24. pmc Elevated serum levels of macrophage-derived chemokine and thymus and activation-regulated chemokine in autistic children
    Laila Yousef Al-Ayadhi
    Autism Research and Treatment Center, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 10:72. 2013
    ..They direct trafficking and recruitment of Th2 cells. We are the first to measure serum levels of CCR4 ligands in relation to the degree of the severity of autism...
  25. pmc A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics
    Laila Y Al-Ayadhi
    Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    Behav Brain Funct 8:4. 2012
    ..We examined whether plasma concentrations of amyloid beta (Aβ) as protein derivatives play a central role in the etiology of autistic features...
  26. pmc Low plasma progranulin levels in children with autism
    Laila Y Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:111. 2011
    ..We are the first to measure plasma progranulin levels in autism...
  27. pmc Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders
    Laila Y Al-Ayadhi
    Department of Physiology, Autism Research and Treatment Center ART Center, AL Amodi Autism Research Chair, Faculty of Medicine, King Saud University, P O Box 2925, Riyadh, 11461, Saudi Arabia
    Neurochem Res 37:394-400. 2012
    ..Our findings are the first to report a correlation between SHH, BDNF and OFR in autistic children, suggesting a pathological role of oxidative stress and SHH in autism spectrum disorders...